Subconjunctival conbercept for the treatment of corneal neovascularization  

作　　者：Cun Sun Fang Ruan Shang Li Jian-Qiang Zhang Ying Jie 

机构地区：[1]Department of Ophthalmology,Beijing Huimin Hospital,Beijing 100053,China [2]Department of Ophthalmology,Beijing You’an Hospital,Capital Medical University,Beijing 100054,China [3]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology and Visual Sciences Key Lab,Beijing 100730,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第6期871-875,共5页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China (No.81970764);the Youth Beijing Scholar (No.2020-022)。

摘　　要：·AIM:To investigate the effectiveness and safety of subconjunctival injection of conbercept in the treatment of corneal neovascularization(CNV).·METHODS:The data on 10 consecutively recruited patients with CNV who received a subconjunctival conbercept(1 mg)once,and measured the area,length,and diameter of neovascularization before and after(1d,1,2wk,and 1mo)treatment as well as the occurrence of systemic and ocular complications after treatment were analyzed.·RESULTS:There was a statistically significant reduction in the area of CNV one day after treatment(mean±SD:38.46±11.36 mm^(2)),compared with before treatment(42.46±12.80 mm^(2),P<0.01).There was also a statistically significant reduction in the length(3.86±1.80 mm vs 4.64±1.77 mm,P<0.01)and diameter(0.044±0.022 vs 0.060±0.026,P<0.05)of CNV,one week after treatment comparing to before treatment.The reduction in all three parameters was maximized at two weeks after treatment(area:29.49±8.83 mm^(2),P<0.001;length:3.50±1.88 mm,P<0.001;and diameter:0.038±0.017 mm,P<0.01).No severe systemic or ocular complication was observed during the study.·CONCLUSION:During the observation period of onemonth,subconjunctival injection of conbercept is an effective and safe method for the reduction of CNV.It may be effective as a preoperative drug for neovascular corneal transplantation.

关 键 词：KEYWORDS:corneal neovascularization conbercept anti-vascular endothelial growth factor subconjunctival injection 

分 类 号：R779.65[医药卫生—眼科]