Cross‑sectional Exploration of the Relationship Between Glutamate Abnormalities and Tic Disorder Severity Using Proton Magnetic Resonance Spectroscopy  

作　　者：Juanjuan Hao Xin Zhang Ying Liu Zhongyang Zhang Keyu Jiang Xiao‑Yong Zhang Min Wu 

机构地区：[1]Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,1665 Kongjiang Road,Shanghai 200092,People’s Republic of China [2]Institute of Science and Technology for Brain‑Inspired Intelligence,Fudan University,Shanghai 200433,People’s Republic of China [3]School of Medicine,Shaoxing University,900 Chengnan Road,Shaoxing 312000,People’s Republic of China [4]Key Laboratory of Computational Neuroscience and Brain‑Inspired Intelligence(Fudan University),Ministry of Education,Shanghai 200433,People’s Republic of China

出　　处：《Phenomics》2023年第2期138-147,共10页表型组学（英文）

基　　金：Funding This study was supported by the grant awarded by the National Natural Science Foundation of China(No.81874486,No.81873893,No.82004418);Shanghai Science and Technology Commission Research Project(No.18401902700,No.17401931200);Shanghai Municipal Health Commission(No.2018LQ010);Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01);Zhejiang Medical Health Science and Technolog Program(No.2022RC280);Shanghai Jiaotong University School of Medicine high level local college construction project(No.18zxy006);Shaoxing University college-level research projects(No.20205038,No.2020LG1007).

摘　　要：Glutamate(Glu)has been reported to be closely related to the pathophysiology of Tic Disorders(TD).By using proton mag-netic resonance spectroscopy(1H-MRS),we aimed to investigate the relationship between in vivo Glu levels and the severity of TD.We performed a cross-sectional study in medication-free patients with TD and healthy controls aged between 5 and 13 years using 1H-MRS at 3 T.First,we measured the Glu levels in both patients and controls and observed the difference in subgroups,including mild TD patients and moderate TD patients.We then examined the correlations between the Glu levels and clinical features of the patients.Finally,we assessed the diagnostic value of 1H-MRS and the influencing factors.Our results show that the Glu levels in the striatum of all patients with TD were not significantly different from those of the healthy controls.Subgroup analysis revealed that the Glu levels in the moderate TD group were higher than those in the mild TD group and healthy controls.The correlation analysis showed that Glu levels are strongly positive correlated with TD severity.The optimal cutoff value of Glu levels to differentiate mild tics from moderate tics was 1.244,with a sensitivity of 88.2%and a specificity of 94.7%.Multiple linear regression models revealed that the severity of TD is one of the important factors that affect Glu levels.We conclude that Glu levels are mainly associated with the severity of tics,thus it could serve as a key biomarker for TD classification.

关 键 词：Tic Disorders Magnetic resonance spectroscopy Glutamate levels STRIATUM 

分 类 号：R445.2[医药卫生—影像医学与核医学]