丁苯酞联合活血通窍汤治疗短暂性脑缺血缺氧发作的效果分析  

Analysis of the Effect of Butylphthalide Combined with Huoxue Tongqiao Decoction in the Treatment of Transient Cerebral Ischemic Hypoxic Attack

作　　者：牛苗苗 郝欣 尹仪亮 NIU Miaomiao;HAO Xin;YIN Yiliang(Department of Pharmacy,Tai'an Second Hospital of Traditional Chinese Medicine,Tai'an,Shandong Province,271000 China;Department of Ophthalmology,Tai'an Second Hospital of Traditional Chinese Medicine,Tai'an,Shandong Province,271000 China;ICU,Tai'an Second Hospital of Traditional Chinese Medicine,Tai'an,Shandong Province,271000 China)

机构地区：[1]泰安市中医二院药剂科,山东泰安271000 [2]泰安市中医二院眼科,山东泰安271000 [3]泰安市中医二院ICU,山东泰安271000

出　　处：《世界复合医学》2023年第3期134-137,共4页World Journal of Complex Medicine

摘　　要：目的探讨丁苯酞联合活血通窍汤治疗短暂性脑缺血缺氧发作的临床效果。方法选择2020年8月—2021年7月泰安市中医二院收治的短暂性脑缺血发作者80例。按照随机数表法分为两组,各40例。对照组使用拜阿司匹林、氯吡格雷双抗进行抗凝治疗,联合瑞舒伐他汀钙调脂,同时给予丁苯酞,观察组则在对照组基础上应用活血通窍汤,比较两组治疗前后CRP水平及治疗前后短暂性脑缺血缺氧发作次数,统计两组治疗后1年血液流变学指标变化及两组临床效果。结果治疗1周后和治疗1疗程后,观察组CRP水平均显著低于对照组,治疗后观察组短暂性脑缺血缺氧发作次数显著少于对照组,差异有统计学意义(P<0.05)。治疗1年后,观察组血液流变学指标中全血低切黏度、全血浆黏度及红细胞电泳指数分别为(6.1±1.3)mPa/s,(1.3±0.2)mPa/s和(2.7±0.3),均显著低于对照组的(10.2±2.2)mPa/s、(2.0±0.3)mPa/s和(4.1±0.5),差异有统计学意义(P<0.05)。观察组痊愈率为65.0%,高于对照组的40.0%,观察组无效率为7.5%,低于对照组的37.5%,差异有统计学意义(χ^(2)=9.825、10.323,P<0.05)。结论针对短暂性脑缺血缺氧发作者,在丁苯酞基础上使用活血通窍汤,可有效降低机体炎症反应和血液黏度,减少疾病发作次数,提高临床治疗效果。Objective To explore the clinical effect of butylphthalide combined with Huoxue Tongqiao decoction in the treatment of transient ischemia-hypoxic attack.Methods A total of 80 patients with transient cerebral ischemia who were admitted to Tai'an Second Hospital of Traditional Chinese Medicine from August 2020 to July 2021 were selected.According to the random number table method,they were divided into two groups with 40 cases in each group.The control group was treated with aspirin and clopidogrel for anticoagulant therapy,combined with rosuvastatin to regulate blood lipids,and given butylphthalide at the same time,while the observation group received Huoxue Tongqiao Decoction on the basis of the control group.The levels of CRP and the number of transient cerebral ischemia-hypoxic attacks before and after treatment were compared between the two groups,and the changes of hemorheology indexes and the clinical effects of the two groups were counted one year after treatment.Results After 1 week of treatment and 1 course of treatment,the CRP levels in the observation group were significantly lower than those of the control group,after treatment,the number of transient cerebral ischemic hypoxic attacks in the observation group was significantly less than that in the control group,the difference was statistically significant(P<0.05).After 1 year of treatment,the hemorheology indexes of the observation group included whole blood low shear viscosity,whole plasma viscosity and erythrocyte electrophoresis index were(6.1±1.3)mPa/s,(1.3±0.2)mPa/s and(2.7±0.3)mPa/s,respectively,were all significantly lower than those of the control group(10.2±2.2)mPa/s,(2.0±0.3)mPa/s and(4.1±0.5),the difference was statistically significant(P<0.05).The cure rate in the observation group was 65.0%,higher than 40.0% in the control group,the invalid rate in the observation group was 7.5%,lower than 37.5%in the control group,the difference was statistically significant(χ^(2)=9.825,10.323,P<0.05).Conclusion For patients with transient cerebra

关 键 词：活血通窍汤 短暂性脑缺血缺氧发作 丁苯酞 炎症因子 发作次数 血液流变学指标 

分 类 号：R743.31[医药卫生—神经病学与精神病学]