某地区女性HPV感染情况及分型分析  

Analysis of HPV infection and genotyping among women in an area

作　　者：马铭君 王舒宁 杨苗 MA Mingjun;WANG Shuning;YANG Miao(Taiyuan Jinyu Clinical Laboratory Co.,LTD.,Taiyuan,Shanxi 030002,China)

机构地区：[1]太原金域临床检验所有限公司,山西太原030002

出　　处：《检验医学与临床》2023年第S01期58-61,共4页Laboratory Medicine and Clinic

摘　　要：目的调查分析山西地区女性HPV的感染情况和常见感染类型,以及不同年龄组中HPV感染的大体情况。从而为该地区宫颈癌的预防、早期诊断和治疗等提供流行病学参考。方法选取送检于太原金域医学检验中心的7030例女性宫颈脱落细胞样本,进行23种HPV基因分型检测。结果7030例样本中共检测出1406例阳性标本,总阳性率为20%。高危型HPV(HR-HPV)共检出1509例(15.06%),低危型HPV(LR-HPV)共检出347例(4.94%)。HR-HPV各亚型检出率从高到低排前五位的分别为HPV52(3.81%)、HPV16(3.29%)、HPV53(2.35%)、HPV58(2.02%)、HPV56(1.59%)和HPV51(1.51%);LR-HPV感染型主要以HPV81(1.35%)、HPV43(1.17%)和HPV42(1.14%)为主。单一亚型的感染率最高为13.90%,双重感染率为3.54%,三重感染率为1.10%,多重感染率为0.50%。HPV检出率最高的是>60~70岁年龄段的女性人群(64.29%),其次为≤20岁的女性人群(54.55%)。结论山西地区女性人群HPV感染率较高,高危型HPV感染占主导位置。HPV感染高发年龄人群应加强宫颈病变的筛查意识,重视HPV的定期复查,以早期发现和预防宫颈癌。Objective To investigate and analyze the HPV infection and common infection types among females in Shanxi,as well as the general situation of HPV infection in different age groups.This will provide epidemiological reference for the prevention,early diagnosis and treatment of cervical cancer in this region.Methods A total of 7030 female cervical exfoliated cell samples sent to Taiyuan Jinyu Medical Laboratory Center were selected for 23 HPV genotyping tests.Results A total of 1406 HPV positive samples were detected in 7030 samples,and the positive rate was 20%.Among them,1509 cases(15.06%)of high-risk HPV(HR-HPV)were detected,and 347 cases(4.94%)of low-risk HPV(LR-HPV)were detected.The top five detection rates of HR-HPV subtypes from high to low are HPV52(3.81%),HPV16(3.29%),HPV53(2.35%),HPV58(2.02%),HPV56(1.59%)and HPV51(1.51%);LR-HPV infection types were mainly HPV81(1.35%),HPV43(1.17%)and HPV42(1.14%).The highest infection rate of single subtype was 13.90%,the double infection rate was 3.54%,the triple infection rate was 1.10%,and the multiple infection rate was 0.50%.The highest HPV detection rate was 64.29%in females aged was from 60 to 70,followed by 54.55%in females≤20 years old.Conclusion The female population in Shanxi has a high HPV infection rate,and high-risk HPV infection is dominant.Age groups with high incidence of HPV infection should strengthen the awareness of cervical lesions screening,pay attention to the regular review of HPV,in order to early detection and prevention of cervical cancer.

关 键 词：人乳头瘤病毒 HPV分型 PCR-反向点杂交法 

分 类 号：R737.33[医药卫生—肿瘤]