左半结肠癌与右半结肠癌微卫星不稳定性差异分析  

Analysis of Microsatellite Instability Differential between Left Sided Colon Cancer and Right Sided Colon Cancer

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作  者:温祥[1] 彭晓峰[1] 张建筑 袁士成[1] 赵文丽[1] 眭文妍[1] WEN Xiang;PENG Xiaofeng;ZHANG Jianzhu;YUAN Shicheng;ZHAO Wenli;SUI Wenyan(The First People's Hospital of Huizhou,Huizhou 516000,China;不详)

机构地区:[1]惠州市第一人民医院,广东惠州516000

出  处:《中外医学研究》2023年第17期67-70,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基  金:广东省惠州市科技计划项目(20200415)。

摘  要:目的:探析左半结肠癌(left sided colon cancer,LSCC)与右半结肠癌(right sided colon cancer,RSCC)微卫星不稳定性(microsatellite instability,MSI)差异。方法:选取2021年4月—2022年6月于惠州市第一人民医院就诊的53例结肠癌患者为研究对象。根据肿瘤生长部位将其分为LSCC组(28例)和RSCC组(25例)。采集两组临床特征及MSI蛋白表达情况。比较两组临床特征及MLH1、MSH2、MSH6、PMS2蛋白阳性率。比较两组MSI情况,分析免疫组化阳性切片。结果:两组性别、年龄、病理类型、淋巴结转移、脉管浸润、神经浸润、组织分化、组织学分型比较,差异无统计学意义(P>0.05)。两组MLH1、MSH2、MSH6阳性率比较,差异无统计学意义(P>0.05),LSCC组PMS2阳性率明显高于RSCC组,差异有统计学意义(P<0.05)。LSCC组微卫星稳定(MSS)占比高于RSCC组,低频率MSI(MSI-L)、高频率MSI(MSI-H)占比低于RSCC组,差异有统计学意义(P<0.05)。结论:相较于LSCC患者,RSCC患者更易出现MSI状态,而加强MSI筛查更有利于提高结肠癌分型精确度。Objective:To explore the microsatellite instability(MSI)differential between left sided colon cancer(LSCC)and right sided colon cancer(RSCC).Method:From April 2021 to June 2022,53 colon cancer patients visited in the First People's Hospital of Huizhou were selected as the study objects.According to the site of tumor growth,they were divided into LSCC group(28 cases)and RSCC group(25 cases).The clinical characteristics and MSI protein expression condition of the two groups were collected.The clinical characteristics and positive rates of MLH1,MSH2,MSH6 and PMS2 proteins were compared between the two groups.The MSI status of the two groups was compared,and the immunohistochemical positive sections were analyzed.Result:There were no significant differences in gender,age,pathological type,lymph node metastasis,vascular invasion,nerve invasion,tissue differentiation,and histological classification between the two groups(P>0.05).There were no significant differences in the positive rates of MLH1,MSH2,and MSH6 between the two groups(P>0.05),but the positive rate of PMS2 in the LSCC group was significantly higher than that in the RSCC group,and the difference was statistically significant(P<0.05).The proportion of microsatellite stability(MSS)in the LSCC group was higher than that in the RSCC group,and the proportions of low frequency MSI(MSI-L)and high frequency MSI(MSI-H)in the LSCC group were lower than those in the RSCC group,and the differences were statistically significant(P<0.05).Conclusion:Compared with LSCC patients,RSCC patients are more likely to have MSI status,and strengthening MSI screening is more conducive to improving the accuracy of colon cancer somatotype.

关 键 词:结肠癌 不同部位 微卫星不稳定性 差异 

分 类 号:R735.35[医药卫生—肿瘤]

 

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