宫颈癌早期筛查与诊断中HPV E6/E7 mRNA的作用  

The role of HPV E6/E7 mRNA in the early screening and diagnosis of cervical cancer

作　　者：蒙静 Meng Jing(Yinshan Community Health Service Center,Liannan District,Liuzhou City,Liuzhou 545005,China)

机构地区：[1]广西柳州市柳南区银山街道社区卫生服务中心,广西柳州545005

出　　处：《实用妇科内分泌电子杂志》2023年第5期37-39,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的研究宫颈癌病变在早期筛查和诊断过程中应用人乳头瘤病毒(HPV)E6/E7 mRNA技术的临床价值。方法选取200例接受早期筛查和病情诊断的宫颈癌患者,实施液基薄层细胞学(TCT)检查作为甲组,实施HPV E6/E7 mRNA技术检查作为乙组,将联合检查作为丙组。同时进行病理学检查。对比各种不同检测方法的检测结果,甲、乙、丙组检查的敏感性、特异性、准确率、阳性预测值及阴性预测值。结果所有研究对象经过病理学检查结果证实,阳性179例,阴性21例,所占比例分别89.50%、10.50%。甲组检测阳性160例,占比达到80.00%,乙组检测阳性168例,占比达到84.00%,丙组检测阳性177例,占比达到88.50%,各组检测阳性率比较,差异无统计学意义(P>0.05)。丙组检查的阴性预测值、准确率、敏感性均高于乙组及甲组,差异有统计学意义(P<0.05)。结论宫颈癌病变在早期筛查和诊断过程中应用HPV E6/E7 mRNA技术,具有一定优势,但仍然建议采用联合检测方式,虽然操作时间会一定延长,但能够明显提高检查准确率,缩短确诊时间,为治疗争取更多的有效时间。Objective To study the clinical value of human papillomavirus(HPV)and E6/E7 mRNA technology in early screening and diagnosis of cervical cancer lesions.Methods 200 patients with cervical cancer who received early screening and disease diagnosis were selected as group A by liquid-based thin layer cytology(TCT)examination,group B by HPV E6/E7 mRNA technique,and group C by combined examination.Pathology was also performed.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of group A,B and C were compared with the test results of different detection methods.Results pathological examination confirmed that 179 cases were positive and 21 cases were negative,accounting for 89.50%and 10.50%respectively.160 cases were tested positive in Group A,accounting for 80.00%,168 cases were tested positive in Group B,accounting for 84.00%,and 177 cases were tested positive in Group C,accounting for 88.50%.There was no statistically significant difference in the positive rates among the groups(P>0.05).The negative predictive value,accuracy,and sensitivity of group C examination were higher than those of group B and group A,with statistically significant differences(P<0.05).Conclusion The application of HPV E6/E7 mRNA technology in the early screening and diagnosis of cervical cancer lesions has certain advantages,but it is still recommended to use the combined detection method,although the operation time will be extended,but can significantly improve the accuracy of the examination,shorten the time of diagnosis,and strive for more effective time for treatment.

关 键 词：宫颈癌病变 早期筛查 诊断 HPV E6/E7 mRNA 

分 类 号：R737.33[医药卫生—肿瘤]