脑出血后脑水肿患者的治疗中采取吡拉西坦联合甘露醇的临床疗效  

Clinical effect of piracetam combined with mannitol in the treatment of cerebral edema after cerebral hemorrhage

作　　者：冯凯燕 Feng Kaiyan(Maoming People's Hospital,Maoming,Guangdong 525000,China)

机构地区：[1]广东省茂名市人民医院,广东茂名525000

出　　处：《首都食品与医药》2023年第12期67-69,共3页Capital Food Medicine

摘　　要：目的脑出血后脑水肿患者在诊治过程中会出现实验室指标异常、神经功能受损等多种情况,对此分析吡拉西坦联合甘露醇的联合用药治疗效果。方法此项研究于2021年6月正式启动,截止时间是2022年6月。选用此时间段到茂名市人民医院接受救治的脑出血后脑水肿患者为研究对象,样本数量共有70例。将上述研究样本分为对照组和研究组两组,分别接受甘露醇以及甘露醇联合吡拉西坦治疗方案。从临床疗效、实验室指标、神经功能与预后、不良反应评估两组治疗方案对促进病情转归的效果。结果借助NIHSS评分量表评价两组治疗方案应用效果,研究组治疗有效率显著优于对照组(P<0.05);观察两组治疗方案对实验室指标的影响,包括血液流变学(血流量、血流速度)、血清指标AQP-4、ox-LDL、ICAM-1,研究组患者经治疗后得到显著改善(P<0.05);分析治疗方案对患者神经功能及预后的影响,研究组患者经治疗后水肿体积明显减少,且NIHSS评分显著降低,MMSE评分与ADL评分明显提高(P<0.05);评估两组用药治疗方案安全性发现,两组不良反应发生率相比无统计学差异(P>0.05)。结论脑出血后脑水肿患者面临一系列生理状态改变,尽早采取吡拉西坦联合甘露醇治疗能够获得理想疗效,对于促进患者病情转归具有积极意义,临床可进一步推广运用。Objective In the process of diagnosis and treatment of cerebral edema patients after cerebral hemorrhage,there will be abnormal laboratory indicators,neurological function impairment and other conditions,which can be divided into piracetam combined with mannitol treatment effect.Methods This study was officially launched in June 2021 and the deadline was June 2022.Patients with cerebral edema after cerebral hemorrhage treated in the author's hospital during this period were selected as the research objects,with a total of 70 samples.The above two groups of study samples were divided into two groups,which received mannitol and piracetam combined treatment regimen respectively,and were recorded as control group and study group,respectively.The clinical efficacy,laboratory indexes,neurological function and prognosis,and adverse reactions of the two groups were evaluated to promote the outcome of the disease.Results Using NIHSS score to evaluate the efficacy of the two groups,it was found that the effective rate of the study group was significantly better than that of the control group(P<0.05).The effects of treatment on laboratory indexes including hemorheology(blood flow,blood velocity),serum indexes AQP-4,ox-LDL and ICAM-1 were observed in the two groups.Compared with the two groups,patients in the study group were significantly improved after treatment(P<0.05).The effect of treatment plan on neurological function and prognosis of patients was analyzed.The edema volume of patients in the study group was significantly reduced after treatment,and NIHSS score was decreased,MMSE score and ADL score were increased(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Patients with cerebral edema after cerebral hemorrhage are faced with a series of physiological changes.Early treatment of piracetam combined with mannitol can achieve ideal efficacy,which has positive significance for promoting the prognosis of patients,and can be further popularized an

关 键 词：脑出血后脑水肿 吡拉西坦 甘露醇 神经功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]