Measurement of Cerebral Oxygen Extraction Fraction Using Quantitative BOLD Approach:A Review  

作　　者：Hongwei Li Chengyan Wang Xuchen Yu Yu Luo He Wang 

机构地区：[1]Institute of Science and Technology for Brain-Inspired Intelligence,Fudan University,220 Handan Road,Yangpu District,Shanghai 200433,China [2]Human Phenome Institute,Fudan University,Shanghai 201203,China [3]Department of Radiology,Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine,Shanghai 200434,China [4]Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence,(Fudan University),Ministry of Education,Shanghai 200433,China

出　　处：《Phenomics》2023年第1期101-118,共18页表型组学（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81971583);National Key R&D Program of China(No.2018YFC1312900);Shanghai Natural Science Foundation(No.20ZR1406400);Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01,No.2018SHZDZX01)and ZJLab.

摘　　要：Quantification of brain oxygenation and metabolism,both of which are indicators of the level of brain activity,plays a vital role in understanding the cerebral perfusion and the pathophysiology of brain disorders.Magnetic resonance imaging(MRI),a widely used clinical imaging technique,which is very sensitive to magnetic susceptibility,has the possibility of substitut-ing positron emission tomography(PET)in measuring oxygen metabolism.This review mainly focuses on the quantitative blood oxygenation level-dependent(qBOLD)method for the evaluation of oxygen extraction fraction(OEF)in the brain.Here,we review the theoretic basis of qBOLD,as well as existing acquisition and quantification methods.Some published clinical studies are also presented,and the pros and cons of qBOLD method are discussed as well.

关 键 词：Quantitative BOLD Oxygen extraction fraction Static dephasing regime Brain diseases 

分 类 号：R74[医药卫生—神经病学与精神病学]