局部RAS组分在原发性开角型青光眼中作用的研究进展  

Advances in Research on Local Ocular Renin-angiotensin System in Primary Open Angle Glaucoma

作　　者：王迪[1] 李海军[2] 段世超 任静 崔慧玲 赵茹梦 WANG Di;LI Haijun;DUAN Shichao;REN Jing;CUI Huiling;ZHAO Rumeng(Department of Ophthalmology,Henan University People’s Hospital,Zhengzhou,450003,China;Henan Eye Institute,Henan Provincial People’s Hospital,Zhengzhou,450003,China;Department of Glaucoma,Zhengzhou University People’s Hospital,Zhengzhou,450003,China)

机构地区：[1]河南大学人民医院青光眼科,郑州市450003 [2]河南省人民医院河南省眼科研究所,郑州市450003 [3]郑州大学人民医院青光眼科,郑州市450003

出　　处：《医学分子生物学杂志》2023年第4期371-374,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.U190411660)。

摘　　要：肾素血管紧张素系统(renin-angiotensin system,RAS),由数十种血管紧张素肽、肽酶和多种受体组成,特异性调节各组织器官功能,维持水电解质的稳态平衡。局部RAS组分广泛分布在人眼的组织结构中,并产生一系列生理及病理作用。文章就RAS系统的主要活性因子成分,及其如何维持原发性开角型青光眼(primary open angle glaucoma,POAG)小梁组织正常生理功能及房水正常动力学状态,以及其作为治疗青光眼的潜在药物靶点的前景进行综述。The renin-angiotensin system(RAS)is composed of dozens of angiotensin peptides,peptidases and various receptors,which specifically regulates the functions of various tissues and organs and maintain the homeostasis of water and electrolyte.The local RAS components are widely distributed in the tissue structure of human eyes and play a series of physiological and pathological roles.This review makes a summary of the main active factors in the RAS system,and how they maintain the physiological function of trabecular tissues and play roles in the aqueous humor dynamics in the primary open angle glaucoma(POAG).In addition,the prospect of using RAS components as potential targets for anti-glaucoma drugs is also reviewed.

关 键 词：原发性开角型青光眼 肾素血管紧张素系统 房水 眼压 

分 类 号：R775.2[医药卫生—眼科]