Phage-mediated horizontal gene transfer and its implications for the human gut microbiome  

作　　者：Tatiana Borodovich Andrey N.Shkoporov R.Paul Ross Colin Hill 

机构地区：[1]APC Microbiome Ireland,University College Cork,Cork,Ireland [2]School of Microbiology,University College Cork,Cork,Ireland

出　　处：《Gastroenterology Report》2022年第1期78-89,共12页胃肠病学报道（英文）

基　　金：financial support from Science Foundation Ireland[grant number SFI/12/RC/2273_P2]and Wellcome Trust under a Wellcome Trust Research Career Development Fellowship[220646/Z/20/Z](A.N.S.);whole,or in part,by the Wellcome Trust[220646/Z/20/Z].

摘　　要：Horizontal gene transfer(HGT)in the microbiome has profound consequences for human health and disease.The spread of antibiotic resistance genes,virulence,and pathogenicity determinants predominantly occurs by way of HGT.Evidence exists of extensive horizontal transfer in the human gut microbiome.Phage transduction is a type of HGT event in which a bacteriophage transfers non-viral DNA from one bacterial host cell to another.The abundance of tailed bacteriophages in the human gut suggests that transduction could act as a significant mode of HGT in the gut microbiome.Here we review in detail the known mechanisms of phage-mediated HGT,namely specialized and generalized transduction,lateral transduction,gene-transfer agents,and molecular piracy,as well as methods used to detect phage-mediated HGT,and discuss its potential implications for the human gut microbiome.

关 键 词：gut phageome horizontal gene transfer gene transduction phage-mediated gene transfer 

分 类 号：R574[医药卫生—消化系统]