Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis  

作　　者：Jingxuan Huang Yangfan Cheng Chunyu Li Huifang Shang 

机构地区：[1]Laboratory of Neurodegenerative Disorders,Department of Neurology,Rare Diseases Center,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Translational Neurodegeneration》2022年第1期641-653,共13页转化神经变性病（英文）

基　　金：the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYJC18038);the Sichuan Science and Technology Program(Grant No.2021YJ0415);the Science Foundation of Chengdu Science and Technology Bureau(Grant No.2019-YF05-00307-SN).

摘　　要：A growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to investigate the role of genetics in sleep disorders in PD patients and asymptomatic carriers at prodromal stage of PD. A systematic review and meta-analysis of observational studies was conducted based on the MEDLINE, EMBASE and PsychINFO databases. A pooled effect size was calculated by odds ratio (OR) and standard mean difference (SMD). Forty studies were selected for quantitative analysis, including 17 studies on glucocerebrosidase (GBA), 25 studies on Leucine-rich repeat kinase 2 (LRRK2) and 7 on parkin (PRKN) genes, and 3 studies on alpha-synuclein gene (SNCA) were used for qualitative analysis. Patients with PD carrying GBA variants had a significantly higher risk for rapid-eye-movement behavior disorders (RBD) (OR, 1.82) and higher RBD Screening Questionnaire scores (SMD, 0.33). Asymptomatic carriers of GBA variants had higher severity of RBD during follow-up. Patients with PD carrying the LRRK2 G2019S variant had lower risk and severity of RBD compared with those without LRRK2 G2019S. Variants of GBA, LRRK2 and PRKN did not increase or decrease the risk and severity of excessive daytime sleepiness and restless legs syndrome in PD. Our findings suggest that the genetic heterogeneity plays a role in the development of sleep disorders, mainly RBD, in PD and the prodromal stage of PD.

关 键 词：Genetic variants Sleep disorder Rapid-eye-movement behavior disorders GBA LRRK2 

分 类 号：R742.5[医药卫生—神经病学与精神病学]