双歧杆菌四联活菌片联合雷贝拉唑四联疗法治疗幽门螺杆菌感染性消化性溃疡的效果及对肠道菌群的影响  

Effect of combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy in the treatment of peptic ulcer with Helicobacter pylori infection and its influence on intestinal flora

作　　者：张光只 李均[1] ZHANG Guangzhi;LI Jun(Comprehensive Outpatient Department,Luoyang Institute of Electro-optical Equipment,Aviation Industry Corporation of China,Luoyang 471000,China)

机构地区：[1]中国航空工业集团公司洛阳电光设备研究所综合门诊部,河南洛阳471000

出　　处：《临床医学研究与实践》2023年第18期61-64,共4页Clinical Research and Practice

摘　　要：目的探讨双歧杆菌四联活菌片联合雷贝拉唑四联疗法治疗幽门螺杆菌(Hp)感染性消化性溃疡的效果及对肠道菌群的影响。方法选择2021年6月至2022年6月于我院门诊就诊的220例Hp感染性消化性溃疡患者,根据随机数字表法将其分为对照组(n=110,雷贝拉唑四联疗法)和研究组(n=110,双歧杆菌四联活菌片联合雷贝拉唑四联疗法)。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的肠杆菌、乳杆菌、双歧杆菌、酵母菌数量多于对照组(P<0.05)。治疗后,研究组的核转录因子(NF-κB)、Toll样受体-4(TLR-4)、一氧化氮(NO)水平低于对照组,转化生长因子-α(TGF-α)水平高于对照组(P<0.05)。治疗后,研究组的胃动素(MTL)、胃泌素(GAS)水平低于对照组(P<0.05)。结论双歧杆菌四联活菌片联合雷贝拉唑四联疗法治疗Hp感染性消化性溃疡患者的效果显著,能够改善机体血清指标、肠道菌群、胃动力学功能,临床可进一步推广应用。Objective To investigate the effect of combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy in the treatment of peptic ulcer with Helicobacter pylori(Hp)infection and its influence on intestinal flora.Methods A total of 220 peptic ulcer patients with Hp infection diagnosed in our hospital outpatient from June 2021 to June 2022 were selected and divided into control group(n=110,rabeprazole quadruple therapy)and study group(n=110,combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy)according to the random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the number of Enterobacter,Lactobacillus,Bifidobacterium and Saccharomyces in the study group were more than those in the control group(P<0.05).After treatment,the levels of nuclear transcription factor-κB(NF-κB),Toll-like receptor-4(TLR-4)and nitrogen monoxide(NO)in the study group were lower than those in the control group,and the level of transforming growth factor-α(TGF-α)was higher than that in the control group(P<0.05).After treatment,the levels of motilin(MTL)and gastrin(GAS)in the study group were lower than those in the control group(P<0.05).Conclusion Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus tablets,live combined with rabeprazole quadruple therapy in the treatment of peptic ulcer patients with Hp infection has a significant effect,which can improve the body serum indexes,intestinal flora and gastric motility function,and can be further promoted and applied clinically.

关 键 词：幽门螺杆菌 消化性溃疡 双歧杆菌四联活菌片 雷贝拉唑 四联疗法 

分 类 号：R573[医药卫生—消化系统]