Pyloric-gland metaplasia may be an origin of cancer and intestinal metaplasia with possible CDX2 expression  

幽门腺化生可能通过CDX2表达引起肠上皮化生甚至直接进展为胃癌

作　　者：Kazuyoshi Yagi Atsunori Tsuchiya Satoru Hashimoto Taisuke Kato Osamu Onodera Shuji Terai 

机构地区：[1]Department of Gastroenterology and Hepatology,Uonuma Institute of Community Medicine,Niigata University Medical and Dental Hospital,Niigata,Japan [2]Division of Gastroenterology and Hepatology,Graduate School of Medical and Dental Sciences,Niigata University,Niigata,Japan [3]Department of System Pathology for Neurological Disorders,Brain Science Branch,Brain Research Institute,Niigata University,Niigata,Japan [4]Department of Neurology,Brain Research Institute,Niigata University,Niigata,Japan

出　　处：《Gastroenterology Report》2021年第4期370-373,I0003,共5页胃肠病学报道（英文）

基　　金：supported by a Grant-in-Aid for Scientific Research(C)[19K08389]from the Ministry of Education,Culture,Sports,Science and Technology of Japan.

摘　　要：Introduction The majority of cases of gastric cancer are thought to develop due to chronic inflammation from Helicobacter pylori(H.pylori)infection leading to intestinal metaplasia,termed the intestinal metaplasia–dysplasia–cancer sequence[1].Chronic inflammation from H.pylori infection causes mucin core protein 6-positive(MUC6t)pyloric-gland metaplasia;however,its origin is controversial.This MUC6t pyloric-gland metaplasia is similar to spasmolytic polypeptide-expressing metaplasia in mouse studies[2–4].

关 键 词：肠上皮化生 幽门腺 HELICOBACTER CDX2 

分 类 号：R735.2[医药卫生—肿瘤]