外泌体与DNA损伤应答的相互调控作用  

Reciprocal regulation between exosomes and DNA damage response

作　　者：胡晓强 周小丰 张丽君 何春草 张燕 杨军[1,3] HU Xiaoqiang;ZHOU Xiaofeng;ZHANG Lijun;HE Chuncao;ZHANG Yan;YANG Jun(Department of Preventive Medicine,Hangzhou Normal University School of Public Health,Hangzhou 311121,China;Department of Radiotherapy,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Zhejiang Provincial Center for Uterine Cancer Diagnosis and Therapy,The Affiliated Women's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China)

机构地区：[1]杭州师范大学公共卫生学院预防医学系,浙江杭州311121 [2]浙江大学医学院附属第二医院放疗科,浙江杭州310009 [3]浙江大学医学院附属妇产科医院浙江省子宫恶性肿瘤诊治中心,浙江杭州310006

出　　处：《中国病理生理杂志》2023年第6期1103-1112,共10页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.31971138);浙江省自然科学基金资助项目(No.LZ19H260001);浙江省卫健委资助项目(No.2022506699);杭州师范大学科研启动基金资助项目(No.2019QDL031);杭州师范大学研究生科研创新推进项目(No.1115B20500435,No.1115B20500433)。

摘　　要：DNA的完整性和稳定性对于机体的正常运转和生存至关重要,但DNA易受到诸多外源性和内源性因素的影响而造成不同程度的损伤[1]。当DNA发生损伤时,细胞内的特殊分子对损伤的识别将激活DNA损伤应答(DNA damage response,DDR)系统,通过复杂的信号传导网络募集多种修复因子到损伤部位并启动DNA损伤的修复。DNA damage response(DDR)is essential for the survival of organisms,and the regulation of DDR has become a key strategy for the treatment of many diseases,especially for cancer.As an important mediator of intercellular communication,exosomes can transport their contents into recipient cells to elicit various functions,and their application in the treatment of human diseases has been investigated extensively.In recent years,the relationship between exosomes and DDR has been gradually recognized.On one hand,DNA damage can influence the secretion and the composition of exosomes;on the other hand,exosomes up-taken by recipient cells can modulate cellular DDR,thus exhibiting a reciprocal regulation between exosomes and DDR.This review summarized the current research progress on the relationship between exosomes and DDR,the underlying mechanisms,and clinical applications for such relationship.

关 键 词：DNA损伤应答 外泌体 肿瘤 

分 类 号：R363[医药卫生—病理学] R34[医药卫生—基础医学] R73-3