生命早期逆境与青春期启动关联的研究进展  

Research progress on the correlation between early life adversity and the puberty initiation

作　　者：张贵娇 吴薇[1] Zhang Guijiao;Wu Wei(Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,武汉430030

出　　处：《中华实用儿科临床杂志》2023年第7期557-560,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：世界范围内青春期启动呈提前趋势。大量流行病学及动物实验证明早期生命活动影响个体的发育轨迹, 引起身体结构和功能的改变, 与成人慢性疾病有关。近年来, 生命早期不良因素暴露对生殖系统功能的影响受到越来越多的关注。现从营养不良或过剩、内分泌干扰物暴露、性激素暴露、应激事件4个方面概述孕期及儿童期不良因素暴露对青春期启动的影响, 特别关注青春期启动的神经内分泌改变, 为预防与控制青春期疾病提供新思路。Earlier onset of puberty has become a worldwide trend.A large number of epidemiologic and animal experiment evidences have indicated that environmental changes in the early life may influence development plasticity and cause structural and functional changes,which are correlated with adult chronic diseases.The impact of fluctuations in environmental factors on the reproductive phenotype of offspring has been well concerned in recent years.This review summarizes the influences of nutritional state,endocrine disrupting chemicals,hormonal perturbation and stressful events during the prenatal and early childhood on the puberty initiation,especially neuroendocrine changes in puberty,thus providing a new idea for the prevention and control of pubertal disorders.

关 键 词：生命早期暴露 营养 内分泌干扰物 青春期启动 神经内分泌 

分 类 号：R179[医药卫生—妇幼卫生保健]