Hap1在神经系统疾病中的研究进展  

Progress in research on Hap1 in neurological diseases

作　　者：何恩浩 曾燕[1] 陈星星[1] HE En-Hao;ZENG Yan;CHEN Xing-Xing(Brain Science and Advanced Technology Institute,Medical College,Wuhan University of Science and Technology,Wuhan 430065,China)

机构地区：[1]武汉科技大学医学院,脑科学先进技术研究院,武汉430065

出　　处：《生命科学》2023年第5期592-600,共9页Chinese Bulletin of Life Sciences

基　　金：湖北省自然科学基金项目(2022CFB216);国家自然科学基金项目(82071272);湖北省教育厅科学研究计划项目(B2020020)。

摘　　要：亨廷顿蛋白相关蛋白1 (Huntingtin-associated protein 1, Hap1)在神经系统中高表达,并与多种蛋白质相互作用。Hap1的功能包括囊泡运输、基因转录和信号转导等,与神经系统的诸多活动密切相关。本文综述了Hap1的结构与分布,总结了与Hap1相互作用并在神经活动中发挥重要作用的蛋白质,以及Hap1在相关神经系统疾病中作用的最新研究进展,为神经系统疾病的治疗提供新思路和新靶点。Huntingtin-associated protein 1(Hap1)is highly expressed in the nervous system and also interacts with a variety of proteins.Hap1 has been found to be involved in intracellular vesicle transport,signal transduction,and synaptic function and participates in various neuronal activities in the nervous system.This article reviews the structure and distribution of Hap1,summarizes the proteins that interact with Hap1 and are important for neural activity,as well as the latest research progress on the association of Hap1 with neurological diseases,aiming at providing new insights for the treatment of neurological diseases.

关 键 词：亨廷顿蛋白相关蛋白1 神经退行性疾病 亨廷顿病 

分 类 号：R749[医药卫生—神经病学与精神病学]