Effect of SAM junctional tourniquet on respiration when applied in the axilla: A swine model  

作　　者：Dong-Chu Zhao Hua-Yu Zhang Yong Guo Hao Tang Yang Li Lian-Yang Zhang 

机构地区：[1]Center of Trauma and War Injury,Daping Hospital,Army Medical Universty,State Key Laboratory of Trauma,Burns and Combined Injury,Chongqing,400042,China [2]Department of Emergency Medicine,Third Afliated Hospital of Chongqing Medical University,Chongqing,400042,China

出　　处：《Chinese Journal of Traumatology》2023年第3期131-138,共8页中华创伤杂志（英文版）

基　　金：Clinical Technology Innovation and Cultivation Project,Army Medical University,number(CX2019JS109);Innovative Project of Daping Hospital for Clinical Medicine,Daping Hospital(number 2019CXLCA002);Innovation Developing Program of Army Medical University,Daping Hospital(number2021XJS27)。

摘　　要：Purpose:SAM junctional tourniquet(SJT)has been applied to control junctional hemorrhage.However,there is limited information about its safety and efficacy when applied in the axilla.This study aims to investigate the effect of SJT on respiration when used in the axilla in a swine model.Methods:Eighteen male Yorkshire swines,aged 6-month-old and weighing 55-72 kg,were randomized into 3 groups,with 6 in each.An axillary hemorrhage model was established by cutting a 2 mm transverse incision in the axillary artery.Hemorrhagic shock was induced by exsanguinating through the left carotid artery to achieve a controlled volume reduction of 30% of total blood volume.Vascular blocking bands were used to temporarily control axillary hemorrhage before SJT was applied.In Group I,the swine spontaneously breathed,while SJT was applied for 2 h with a pressure of 210 mmHg.In Group II,the swine were mechanically ventilated,and SJT was applied for the same duration and pressure as Group I.In Group III,the swine spontaneously breathed,but the axillary hemorrhage was controlled using vascular blocking bands without SJT compression.The amount of free blood loss was calculated in the axillary wound during the 2 h of hemostasis by SJT application or vascular blocking bands.After then,a temporary vascular shunt was performed in the 3 groups to achieve resuscitation.Pathophysiologic state of each swine was monitored for 1 h with an infusion of 400 mL of autologous whole blood and 500 mL of lactated ringer solution.Tb and T0 represent the time points before and immediate after the 30% volume-controlled hemorrhagic shock,respectively.T30,T60,T90 and T120,denote 30,60,90,and 120 min after T0(hemostasis period),while T150,and T180 denote 150 and 180 min after T0(resuscitation period).The mean arterial pressure and heart rate were monitored through the right carotid artery catheter.Blood samples were collected at each time point for the analysis of blood gas,complete cell count,serum chemistry,standard coagulation tests,etc.,and thromboelastog

关 键 词：Junctional hemorrhage TOURNIQUET Swine model AXILLA RESPIRATION 

分 类 号：R-332[医药卫生] R826