药物联用抑制白念珠菌生长的研究进展  

Research progress on drug combination therapy against Candida albicans

作　　者：邓忠宇 郭士槿 郭熠凡 冯峻程 吕权真 邱丽娟 DENG Zhongyu;GUO Shijin;GUO Yifan;FENG Juncheng;LYU Quanzhen;QIU Lijuan(School of Basic Medicine,Naval Medical University,Shanghai 200433,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学基础医学院,上海200433 [2]海军军医大学药学系,上海200433

出　　处：《药学实践与服务》2023年第6期352-357,共6页Journal of Pharmaceutical Practice and Service

基　　金：海军军医大学大学生创新能力培养基金。

摘　　要：白念珠菌是念珠菌属最常见的种类之一,是临床上重要的侵袭性念珠菌感染来源。由于传统抗真菌药物的广泛使用,临床已经分离出很多耐药白念珠菌,导致部分传统药物在临床治疗效果明显下降。同时,一些化合物自身的毒性限制了其临床应用。在这种背景下,联合疗法由于发挥了各种药物或手段的协同作用,有可能改进单独用药的不足,具有抑制白念珠菌生长的巨大潜力。Candida albicans is one of the most common species of Candida,which is an important cause of invasive candidiasis in clinic.Due to the frequently use of classical antifungal agents,there are amounts of drug resistant C.albicans being isolated,causing the significantly decreasing of the efficacy of some antifungal agents in clinical treatment.Besides,the use of some compounds in clinic has been limited because of their toxicities.In such a context,drug combination therapy shows great potential on antifungal because of the synergy of different drugs or therapeutic methods that could bring,which could improve the weaknesses of single drug.

关 键 词：白念珠菌 联合疗法 唑类化合物 多烯类 棘白霉素类 光动力学疗法 声动力学疗法 纳米银 

分 类 号：R96[医药卫生—药理学]