姜砂半夏纳米贴治疗疾病终末期患者恶心呕吐疗效及对肿瘤患者QOL影响  

Efficacy of Jiangsha Banxia nano-paste on nausea and vomiting in end-stage patients and its effect on QOL in cancer patients

作　　者：张天宏 刘秀凤[2] 王华 丁秀娟 戴海敏 胡萍 王卫锋 鲁青 徐峰[2] 何婉红 ZHANG Tianhong;LIU Xiufeng;WANG Hua;DING Xiujuan;DAI Haimin;HU Ping;WANG Weifeng;LU Qing;XU Feng;HE Wanhong(Shanghai Fengxian Guangming Community Health Center,Shanghai 201406,China;Sixth People’s Hospital South District,Shanghai Jiao Tong University,Shanghai 201400,China;Shanghai Fengxian Jinhui Community Health Center,Shanghai 201404,China;Shanghai Fengxian Fengcheng Community Health Center,Shanghai 201411,China;Shanghai Fengxian Zhuanghang Community Health Center,Shanghai 201415,China;Shanghai Fengxian Fengpu Community Health Center,Shanghai 201401,China)

机构地区：[1]上海市奉贤区南桥镇光明社区卫生服务中心,上海201406 [2]上海交通大学附属第六人民医院南院,上海201400 [3]上海市奉贤区金汇镇社区卫生服务中心,上海201404 [4]上海市奉贤区奉城镇社区卫生服务中心,上海201411 [5]上海市奉贤区庄行镇社区卫生服务中心,上海201415 [6]上海市奉贤区奉浦街道社区卫生服务中心,上海201401

出　　处：《药学实践与服务》2023年第6期380-384,共5页Journal of Pharmaceutical Practice and Service

基　　金：上海市卫生健康委员会社区中医药适宜技术项目(SQ-SYJS-15)。

摘　　要：目的观察姜砂半夏纳米贴对疾病终末期患者恶心呕吐的临床疗效及其对肿瘤患者生存质量(QOL)的影响。方法将120例伴有Ⅲ级以上恶心呕吐症状的疾病终末期患者随机分为观察组和对照组,并分别用姜砂半夏纳米贴和安慰剂贴敷治疗,每24 h更换贴剂,连续使用7 d。观察恶心呕吐症状评分,进一步对两组中癌症患者的QOL测定评分和功能状态(KPS)评分。结果治疗7 d后观察组恶心呕吐症状评分显著降低,KPS评分升高,有效率高于对照组。观察组组内,肿瘤患者治疗后主要症状领域及其他症状领域(除气促、腹泻外)评分降低,整体健康领域评分升高。观察组肿瘤患者治疗后主要症状领域及其他症状领域(除气促、腹泻外)评分低于对照组,整体健康领域评分均高于对照组。结论姜砂半夏纳米贴贴敷治疗疾病终末期患者恶心呕吐具有良好的临床疗效,可提高肿瘤终末期患者生存质量。Objective To observe the clinical efficacy of Jiangshabanxia nano-paste on nausea and vomiting in end-stage patients and its effect on the quality-of-life(QOL)in cancer patients.Methods 120 end-stage patients with nausea and vomiting symptoms above grade III were randomly divided into observation group and control group.They were treated with Jiangshabanxia nano-paste and placebo paste respectively.The paste patch was changed every 24 hours and used continuously for 7 days.The nausea and vomiting symptom score,the quality-of-life measurement score and KPS score of cancer patients in the two groups were observed to evaluate the curative effect.Results After 7 days of treatment,the symptom scores of nausea and vomiting in the observation group decreased significantly,the KPS score of the observation group increased,and the effective rate was higher than that in the control group.The score of QOL measurement showed that after treatment,the score of main symptom areas and other symptom areas(except external dyspnea,diarrhea and economic difficulties)in the observation group decreased,and the score of overall health area increased.After treatment,the score of main symptom areas and other symptom areas(except external dyspnea,diarrhea and economic difficulties)in the observation group was lower than that in the control group,and the scores of overall health area in the observation group were higher than those in the control group.Conclusion Jiangshabanxia nano-paste has a good clinical efficacy nausea and vomiting in end-stage patients,it also can improve the quality of life end-stage cancer patients.

关 键 词：疾病终末期 恶心 呕吐 姜砂半夏纳米贴 穴位贴敷 外治 

分 类 号：R730.5[医药卫生—肿瘤]