Biomimetic asymmetric catalysis  

作　　者：Xiao Xiao Kaini Xu Zhong-Hua Gao Zhou-Hao Zhu Changqing Ye Baoguo Zhao Sanzhong Luo Song Ye Yong-Gui Zhou Senmiao Xu Shou-Fei Zhu Hongli Bao Wei Sun Xiaoming Wang Kuiling Ding 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [2]The Education Ministry Key Laboratory of Resource Chemistry,Shanghai Key Laboratory of Rare Earth Functional Materials,and Shanghai Frontiers Science Center of Biomimetic Catalysis,Shanghai Normal University,Shanghai 200234,China [3]Center of Basic Molecular Science,Department of Chemistry,Tsinghua University,Beijing 100084,China [4]Beijing National Laboratory for Molecular Sciences,CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [5]University of Chinese Academy of Sciences,Beijing 100049,China [6]State Key Laboratory of Catalysis,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China [7]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China [8]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China [9]Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,State Key Laboratory of Structural Chemistry,Center for Excellence in Molecular Synthesis,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China

出　　处：《Science China Chemistry》2023年第6期1553-1633,共81页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22231011,22221002,22031006,21831008,22271192,92256301,92256303,91956116);the NSFC Distinguished Young Scholars(22225107);the Major Program of the Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences(ZYFZFX-9)。

摘　　要：Enzymes are the core for biological transformations in nature.Their structures and functions have drawn enormous attention from biologists as well as chemists since last century.The large demand of bioactive molecules and the pursuit of efficiency and greenness of synthesis have spurred the rapid development of biomimetic chemistry in the past several decades.Biomimetic asymmetric catalysis,mimicking the structures and functions of enzymes,has been recognized as one of the most promising synthetic strategies for the synthesis of valuable chiral compounds.This review summarizes the evolution of asymmetric catalysis inspired by aldolases,vitamin B_(1)/B_(6)-dependent enzymes,NAD(P)H,flavin,hydrogenases,heme oxygenases,nonheme oxygenases,and dinuclear/multinuclear metalloenzymes in aspects of biomimetic design,catalyst development and related catalytic transformations.Those well-established synthetic approaches originating from biological reactions have demonstrated the unique prowess of biomimetic asymmetric catalysis in bridging the gap between bio-catalysis and chemical synthesis.

关 键 词：biomimetic catalysis amine catalysis carbene catalysis vitamin Br carbonyl catalysis vitamin Bo NAD(P)H FLAVIN biomimetic oxidation dinuclear/multinuclear metal catalysis asymmetric hydrogenation 

分 类 号：TQ426.97[化学工程]