ATG2B、TGFBR1在非小细胞肺癌中的表达及预后价值  

Expression and prognostic value of ATG2B and TGFBR1 in non-small cell lung cancer

作　　者：张磊[1] 韩京军[1] 杨门 李海州 许英杰 ZHANG Lei;HAN Jing-jun;YANG Men(Department of Thoracic Surgery,the Eighth Affiliated Hospital of Sun Yat sen University,Shenzhen Guangdong 510122,China)

机构地区：[1]中山大学附属第八医院胸外科,广东深圳510122

出　　处：《临床和实验医学杂志》2023年第10期1030-1034,共5页Journal of Clinical and Experimental Medicine

基　　金：广东省卫健委重点研发指导项目(编号:20200351)。

摘　　要：目的探究自噬相关基因2B(ATG2B)、转化生长因子β受体1(TGFBR1)在非小细胞肺癌(NSCLC)组织中的表达及二者与NSCLC患者预后的关系。方法回顾性选取2018年10月至2019年10月中山大学附属第八医院收治的100例NSCLC患者术中切除的NSCLC组织及癌旁组织作为标本,收集并记录NSCLC患者性别、肿瘤直径、分化程度、病理分型、TNM分期、淋巴结转移等临床资料;免疫组织化学检测癌组织及癌旁组织中ATG2B、TGFBR1表达;Kaplan-Meier法分析NSCLC组织中ATG2B、TGFBR1表达与NSCLC患者预后的关系;多因素Cox回归分析NSCLC患者预后的影响因素。结果NSCLC组织中ATG2B、TGFBR1阳性率分别为74.00%、68.00%,均较癌旁组织(16.00%、12.00%)明显增高,差异均有统计学意义(P<0.05)。低分化、TNM分期Ⅲ期、有淋巴结转移及器官转移的NSCLC患者ATG2B、TGFBR1阳性表达比例高于中高分化、TNM分期Ⅰ+Ⅱ期、无淋巴结转移及器官转移的NSCLC患者,差异均有统计学意义(P<0.05)。NSCLC组织ATG2B阴性表达患者3年生存率为65.38%,高于ATG2B阳性表达患者(31.08%)(Log Rank=11.808,P<0.05),NSCLC组织TGFBR1阳性表达患者3年生存率为26.47%,低于TGFBR1阴性表达患者(68.75%)(Log Rank=21.768,P<0.05)。生存组低分化、TNM为Ⅲ期、淋巴结转移及器官转移的比例明显低于死亡组,差异均有统计学意义(P<0.05)。Cox回归分析显示TNM分期、淋巴结转移与ATG2B、TGFBR1表达水平均是NSCLC不良预后的危险因素(P<0.05)。结论ATG2B、TGFBR1在NSCLC患者癌组织中高表达,且二者均是NSCLC患者预后不良的危险因素。Objective To investigate the expression of autophagy related gene 2B(ATG2B)and transforming growth factorβreceptor 1(TGFBR1)in non-small cell lung cancer(NSCLC)and their relationship with the prognosis of NSCLC patients.Methods NSCLC tissues and adjacent tissues of 100 patients with NSCLC who were treated in the Eighth Affiliated Hospital of Sun Yat sen University from October 2018 to October 2019 were retrospectively selected as specimens,the clinical data of NSCLC patients were collected and recorded,such as gender,tumor diameter,degree of differentiation,pathological classification,TNM stage,and lymph node metastasis,etc,the expression of ATG2B and TGFBR1 in cancer tissues and adjacent tissues was detected by immunohistochemistry,Kaplan-Meier method was used to analyze the relationship between the expression of ATG2B and TGFBR1 in NSCLC tissues and the prognosis of NSCLC patients;and multivariate Cox regression was applied to analyze the prognostic factors of NSCLC patients.Results The positive rates of ATG2B and TGFBR1 in NSCLC tissues were 74.00%,68.00%,which were obviously higher than those in adjacent tissues(16.00%,12.00%),the differences were statistically significant(P<0.05).The positive expression rates of ATG2B and TGFBR1 in NSCLC patients with low differentiation,TNM stageⅢ,lymph node metastasis and organ metastasis were higher than those in NSCLC patients with medium and high differentiation,TNM stageⅠ+Ⅱ,and no lymph node metastasis and organ metastasis,the differences were statistically significant(P<0.05).The 3-year survival rate of patients with negative ATG2B expression in NSCLC tissues was 65.38%,which was higher than that of patients with positive ATG2B expression(31.08%)(Log Rank=11.808,P<0.05),the 3-year survival rate of patients with TGFBR1 positive expression in NSCLC tissues was 26.47%,which was lower than that of patients with TGFBR1 negative expression(68.75%)(Log Rank=21.768,P<0.05).The proportions of poor differentiation,TNM stage III,lymph node metastasis and organ metastasis

关 键 词：自噬相关基因2B 转化生长因子β受体1 非小细胞肺癌 预后 

分 类 号：R734.2[医药卫生—肿瘤]