PEG-rhG-CSF皮下注射与替吉奥联合调强放疗对晚期食管癌的疗效及生存质量的影响  

Effect of subcutaneous injection of PEG-rhG-CSF combined with tegafur in intensity modulated radiotherapy on the efficacy and quality of life of advanced esophageal cancer

作　　者：王姗[1] 赵慧 袁丹 WANG Shan;ZHAO Hui;YUAN Dan(Department of Radiotherapy,Huaibei Miners General Hospital,Huaibei Anhui 235000,China)

机构地区：[1]淮北矿工总医院放疗科,安徽淮北235000

出　　处：《临床和实验医学杂志》2023年第9期953-957,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省教育厅科研基金项目(编号:KJ2019A0357)。

摘　　要：目的探讨皮下注射聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)联合替吉奥在晚期食管癌调强放疗治疗中的价值。方法前瞻性选取2018年1月至2019年9月淮北矿工总医院收治的60例晚期食管癌患者作为研究对象,采用随机数字表法将患者分为观察组和对照组,各30例。对照组患者采用替吉奥+调强放疗措施治疗,观察组患者在对照组基础上同时给予PEG-rhG-CSF注射治疗。比较两组患者放疗近期效果、外周血T淋巴细胞亚群及NK细胞、生存质量评分、毒副反应发生率、生存率及生存时间差异。结果两组的治疗效果分布比较,差异无统计学意义(P>0.05)。治疗后,观察组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、CD16^(+)CD56^(+)NK细胞占比分别为(62.50±4.80)%、(38.51±3.00)%、1.49±0.15、(22.63±2.24)%,均高于对照组[(58.83±5.28)%、(36.67±2.89)%、1.39±0.13、(21.55±1.87)%],差异均有统计学意义(P<0.05)。治疗后,观察组患者的乏力、恶心、食欲不振、失眠评分为(36.29±4.16)、(44.10±5.06)、(33.52±4.27)、(34.20±4.86)分,均低于对照组[(38.85±3.78)、(47.03±4.81)、(37.30±4.52)、(37.56±5.20)分],差异均有统计学意义(P<0.05)。治疗过程中,观察组患者的恶心、呕吐、放射性食管炎、放射性肺炎发生程度均低于对照组,差异有统计学意义(P<0.05)。随访2年,观察组生存率43.33%,对照组生存率33.33%,观察组的中位生存时间21个月,对照组20个月,两组差异无统计学意义(P>0.05)。结论PEG-rhG-CSF联合替吉奥在晚期食管癌调强放疗治疗中应用能缓解放化疗引起的细胞免疫功能受损、改善生存质量、降低毒副反应发生率。Objective To investigate the value of subcutaneous injection of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)combined with tegafur in intensity modulated radiation therapy for advanced esophageal cancer.Methods A total of 60 patients with advanced esophageal cancer admitted to Huaibei Miner General Hospital from January 2018 to September 2019 were prospectively selected as the study subjects.The patients were divided into the observation group and the control group according to the random number table method,with 30 patients in each group.Patients in control group were treated with Tegor+intensity modulated radiation therapy,and patients in observation group were treated with PEG-rhG-CSF injection on the basis of control group treatment.The radiotherapy effect,peripheral blood T lymphocyte subsets and natural killer cells,quality of life score,incidence of toxic side effects,survival rate and survival time were compared between the two groups.Results There was no statistically significant difference in the distribution of treatment effects between the two groups(P>0.05).After treatment,the percentages of CD3^(+),CD4^(+),CD4^(+)/CD8^(+),CD16^(+)CD56^(+)NK cells in the observation group were(62.50±4.80)%,(38.51±3.00)%,1.49±0.15,(22.63±2.24)%,which were higher than those in the control group[(58.83±5.28)%,(36.67±2.89)%,1.39±0.13,(21.55±1.87)%],and the differences were statistically significant(P<0.05).After treatment,the scores of fatigue,nausea,anorexia,and insomnia in the observation group were(36.29±4.16),(44.10±5.06),(33.52±4.27),(34.20±4.86)points,which were significantly lower than those in the control group[(38.85±3.78),(47.03±4.81),(37.30±4.52),(37.56±5.20)points],and the differences were statistically significant(P<0.05).During radiotherapy,the incidence of nausea and vomiting,radiation esophagitis and radiation pneumonitis in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 2 ye

关 键 词：聚乙二醇化重组人粒细胞集落刺激因子 替吉奥 晚期 食管肿瘤 调强放疗 

分 类 号：R735.1[医药卫生—肿瘤]