子宫内膜癌患者术前FIB、FAR、CA125、CA199的水平及临床意义  

Levels and clinical significancce of preoperative FIB,FAR,CA125,CA199 in patients with endometrial cancer

作　　者：张巧云 林发全[1] ZHANG Qiaoyun;LIN Faquan(Key Laboratory of Clinical Laboratory Diagnostics of Guangxi Universities/Department of Clinical Laboratory,First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China;Department of Clinical Laboratory,Liuzhou Municipal Worker′s Hospital,Liuzhou,Guangxi 545005,China)

机构地区：[1]广西高校临床检验诊断学重点实验室/广西医科大学第一附属医院检验科,广西南宁530021 [2]广西壮族自治区柳州市工人医院检验科,广西柳州545005

出　　处：《检验医学与临床》2023年第12期1695-1699,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨子宫内膜癌患者纤维术前蛋白原(FIB)、FIB/清蛋白(ALB)比值(FAR)、糖类抗原(CA)125、CA199的水平及临床意义。方法选取2020年1月至2021年12月在柳州市工人医院就诊的171例子宫内膜病变患者作为研究对象,其中74例子宫内膜息肉患者作为对照组,97例子宫内膜癌患者作为观察组。收集患者接受手术治疗前的血液检测结果,包括FIB、ALB、CA125、CA199,计算FAR,比较两组FIB、FAR、CA125、CA199的水平差异,绘制受试者工作特征(ROC)曲线分析FIB、FAR、CA125、CA199诊断子宫内膜癌的效能,分析FIB、FAR、CA125、CA199与子宫内膜癌临床病理特征的相关性。结果观察组FIB、FAR、CA125、CA199水平均高于对照组(P<0.05);FIB+FAR+CA125+CA199诊断子宫内膜癌的AUC为0.902,灵敏度是76.3%,特异度是94.6%,诊断效能高于单项指标;FIB、FAR、CA125水平均与子宫内膜癌淋巴结转移呈正相关(r=0.370、0.422、0.467,P<0.05)。结论FIB、FAR、CA125、CA199联合诊断子宫内膜癌有较高的效能;FIB、FAR、CA125在术前评估子宫内膜癌患者病情、指导个体化治疗方面有一定的预测作用。Objective To explore the levels and clinical significance of fibrinogen(FIB),FIB/albumin(ALB)ratio(FAR),carbohydrate antigen(CA)125 and CA199 in the patients with endometrial cancer.Methods A total of 171 patients with endometrial lesions visited to Liuzhou Municipal Worker′s Hospital from January 2020 to December 2021 were selected,74 cases diagnosed as endometrial polyps served as the control group and 97 cases diagnosed as endometrial cancer served as the observation group.The blood test results before surgical treatment were collected,including FIB,ALB,CA125 and CA199,FAR was calculated,the differences on the levels of FIB,FAR,CA125 and CA199 were compared between the two groups,the receiver operating characteristic(ROC)curve was drawn to analyze the efficiency of FIB,FAR,CA125,CA199 in diagnosing endometrial cancer,and the correlations between FIB,FAR,CA125 and CA199 with the clinicopathological features of endometrial cancer were analyzed.Results The levels of FIB,FAR,CA125 and CA199 in the observation group were higher than those in the control group(P<0.05).The area under the curve(AUC)of FIB+FAR+CA125+CA199 for the diagnosing endometrial cancer was 0.902,with a sensitivity of 76.3%and a specificity of 94.6%,its diagnostic efficiency was higher than that of the single index.FIB,FAR and CA125 were positively correlated with lymph node metastasis in endometrial cancer(r=0.370,0.422,0.467,P<0.05).Conclusion FIB,FAR,CA125 and CA199 combined diagnosis of endometrial cancer has high efficiency.FIB,FAR and CA125 have a certain predictive effect in the aspects of preoperative assessment of disease condition in the patients with endometrial cancer and guidance of individualized treatment.

关 键 词：纤维蛋白原 纤维蛋白原与清蛋白比值 糖类抗原125 糖类抗原199 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]