龈沟液Shh蛋白、DKK1、HC-gp39与重度牙周炎患者治疗后预后的关系  

Relationships between gingival crevicular fluid Shh protein,DKK1 and HC-gp39 with prognosis after treatment in patients with severe periodontitis

作　　者：朱丽娜 包丽娜 ZHU Lina;BAO Lina(Department of Stomatology,Shaanxi Nuclear Industry 215 Hospital,Xianyang,Shaanxi,712000,China;Department of Stomatology,Xianyang Municipal First People′s Hospital,Xianyang,Shaanxi 712000,China)

机构地区：[1]陕西省核工业二一五医院口腔科,陕西咸阳712000 [2]陕西省咸阳市第一人民医院口腔科,陕西咸阳712000

出　　处：《检验医学与临床》2023年第12期1700-1703,1709,共5页Laboratory Medicine and Clinic

基　　金：陕西省科技计划项目(2021QJ-412)。

摘　　要：目的研究龈沟液Shh蛋白、dickkopf相关蛋白1(DKK1)、人类软骨糖蛋白-39(HC-gp39)与前牙区重度牙周炎患者牙周基础治疗后预后的关系。方法选取2019年1月至2022年1月核工业二一五医院收治的120例前牙区重度牙周炎患者作为研究对象。牙周基础治疗90 d后,将患者按照治疗后PD的差异分为预后不良组和预后良好组,比较两组患者龈沟液Shh蛋白、DKK1、HC-gp39水平以及基线资料。通过多因素Logistic回归分析前牙区重度牙周炎患者牙周基础治疗后预后不良的影响因素,采用受试者工作特征(ROC)曲线分析龈沟液Shh蛋白、DKK1、HC-gp39预测前牙区重度牙周炎患者牙周基础治疗后预后的效能。结果预后不良组龈沟液Shh蛋白、DKK1、HC-gp39水平均高于预后良好组(P<0.05)。经多因素Logistic回归分析发现:有吸烟史、治疗前PD>7.60 mm、治疗前临床附着丧失(CAL)>7.00 mm、Shh蛋白>4.00μg/L、DKK1>9.00μg/L及HC-gp39>60.00 ng/mL均是前牙区重度牙周炎患者牙周基础治疗后预后不良的危险因素(P<0.05)。龈沟液Shh蛋白、DKK1、HC-gp39单项检测及3项联合检测预测前牙区重度牙周炎患者牙周基础治疗后预后不良的曲线下面积(AUC)分别为0.755、0.783、0.721、0.845,3项联合检测预测的效能优于单项检测。结论龈沟液Shh蛋白、DKK1、HC-gp39与前牙区重度牙周炎患者牙周基础治疗后的预后不良密切相关,可作为临床辅助判断患者预后的生物学指标。Objective To study the relationships between gingival crevicular fluid Shh protein,dickkopf-related protein 1(DKK1)and human cartilage glycoprotein-39(HC-gp39)with the prognosis after periodontal basic treatment in the patients with anterior teeth region severe periodontitis.Methods A total of 120 patients with anterior dental region severe periodontitis receiving the treatment in 215 Hospital of Nuclear Industry from January 2019 to January 2022 were selected.After 90 d of periodontal basic therapy,the patients were divided into poor prognosis group and good prognosis group according to the difference of PD after treatment.The levels of Shh protein,DKK1 and HC-gp39 in gingival crevicular fluid and baseline data of the two groups were compared.The influencing factors of poor prognosis were analyzed by multivariate Logistic regression.The receiver operating characteristic(ROC)curve was used to analyze the efficiency of gingival crevicular fluid Shh protein,DKK1 and HC-gp39 in predicting the prognosis of the patients with anterior teeth severe periodontitis.Results The levels of gingival crevicular fluid Shh protein,DKK1 and HC-gp39 in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The multivariate Logistic regression analysis found that the smoking history,PD>7.60 mm before treatment,clinical attachment loss(CAL)>7.00 mm before treatment,Shh protein>4.00μg/L,DKK1>9.00μg/L and HC-gp39>60.00 ng/mL were all risk factors for poor prognosis after basic periodontal treatment in the patients with anterior dental region severe periodontitis(P<0.05).The area under curve(AUC)of gingival crevicular fluid Shh protein,DKK1 and HC-gp39 single-item detection and 3-item combined detection for predicting poor prognosis in the patients with anterior dental region severe periodontitis were 0.755,0.783,0.721 and 0.845 respectively.The efficiency of the 3-item combined detection for prediction was better than that of the single-item detection.Conclusion Shh protein,DKK1 and HC-gp39 in gingival cr

关 键 词：Shh蛋白 dickkopf相关蛋白1 人类软骨糖蛋白-39 重度牙周炎 牙周基础治疗 预后 

分 类 号：R781.42[医药卫生—口腔医学]