超声造影肝脏影像数据和报告系统分类与肝细胞癌分化程度及Ki-67指数的相关性分析  

Correlation analysis of contrast-enhanced ultrasound Liver Imaging Reporting and Data System classification with hepatocellular carcinoma differentiation and Ki-67 index

作　　者：柴苏婉 蔡文佳 于杰 郑荣琴[3] 廖锦堂[4] 罗葆明[5] 唐丽娜[6] 梁萍 Chai Suwan;Cai Wenjia;Yu Jie;Zheng Rongqin;Liao Jintang;Luo Baoming;Tang Lina;Liang Ping(Chinese PLA Medical School,Beijing 100853,China;Department of Interventional Ultrasound,Fifth Medical Center of Chinese PLA General Hospital,Beijing 100853,China;Department of Medical Ultrasound,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Diagnostic Ultrasound,Xiangya Hospital of Central South University,Changsha 410008,China;Department of Ultrasound,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China;Department of Diagnostic Ultrasound,Fujian Cancer Hospital&Fujian Medical University Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]解放军医学院/解放军总医院,北京100853 [2]解放军总医院第五医学中心介入超声科,北京100853 [3]中山大学附属第三医院超声科,广州510630 [4]中南大学湘雅医院超声影像科,长沙410008 [5]中山大学孙逸仙纪念医院超声科,广州510120 [6]福建医科大学附属肿瘤医院、福建省肿瘤医院超声科,福州350014

出　　处：《中华超声影像学杂志》2023年第5期386-391,共6页Chinese Journal of Ultrasonography

摘　　要：目的探讨不同超声造影(CEUS)肝脏影像数据和报告系统(LI-RADS)类别与肝细胞癌(HCC)分化程度及Ki-67指数相关性。方法采用回顾性病例研究,纳入分析中国CEUS数据库中2017年12月至2020年12月共208例HCC患者(208个病灶)的临床和影像学资料,根据美国放射学会提出的CEUS LI-RADS(V2017)对病灶分类。以组织病理学诊断结果为金标准,评估HCC的分化程度及Ki-67指数在CEUS LI-RADS不同类别中分布是否存在差异,并采用Kendall′s tau-b相关系数检验分析CEUS LI-RADS类别与肿瘤分化程度及Ki-67指数的相关性。结果不同CEUS LI-RADS类别的HCC之间分化程度及Ki-67指数的分布差异有统计学意义(P<0.001,P=0.009),CEUS LI-RADS M类HCC更容易呈低分化且表现出更高的Ki-67指数。CEUS LI-RADS类别与肿瘤分化程度呈负相关(tau-b=-0.250,P<0.001),与Ki-67指数呈正相关(tau-b=0.178,P=0.002),即CEUS LI-RADS类别越高,肿瘤的分化程度越低且Ki-67指数越高。结论不同CEUS LI-RADS类别与HCC分化程度及Ki-67指数存在相关性。Objective To investigate the correlation of hepatocellular carcinoma(HCC)classified by contrast-enhanced ultrasound(CEUS)Liver Imaging Data and Report System(LI-RADS)with differentiation degree and Ki-67 index.Methods A multicenter,retrospective study was conducted.The clinical and CEUS imaging data of 208 patients with 208 HCC lesions from December 2017 to December 2020 in China CEUS database were included and analyzed.According to the CEUS LI-RADS version 2017 proposed by the American College of Radiology,the HCC was classified.The diagnosis and pathological information of all lesions were confirmed by pathology.The differentiation degree of HCC and the distribution of Ki-67 index in different LI-RADS categories were evaluated,and their correlation was analyzed.Results The degree of differentiation and Ki-67 index among HCC of different CEUS LI-RADS were statistically significant(P<0.001,P=0.009).LI-RADS M HCC was more likely to be poorly differentiated and showed a higher Ki-67 index.The category of LI-RADS was positively correlated with the degree of tumor differentiation(tau-b=-0.250,P<0.001)and the Ki-67 index(tau-b=0.178,P=0.002),that is,the higher the category of LI-RADS,the lower differentiation degree and the higher the Ki-67.Conclusions The CEUS LI-RADS classification of HCC is correlating with the degree of differentiation and Ki-67 index.

关 键 词：超声造影 肝细胞癌 肝脏影像数据和报告系统 分化程度 KI-67指数 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]