肠道菌群对肿瘤放疗的影响  

Effect of intestinal flora on tumorradiotherapy

作　　者：白玉萍 齐文博 刘乐[2] 杨洲 石安娅 王琛[3] 陈昊[3] BAI Yuping;QI Wenbo;LIU Yue;YANG Zhou;SHI Anya;WANG Chen;CHEN Hao(Department of MR Lanzhou University Second Hospital,Lanzhou 730030,China;Department of Surgical Oncology,Lanzhou University Second Hospital,Lanzhou 730030,China;The Key Laboratory of the Digestive System Tumors of Gansu Province,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院核磁共振科,甘肃兰州730030 [2]兰州大学第二医院肿瘤外科,甘肃兰州730030 [3]兰州大学第二医院消化系统肿瘤重点实验室,甘肃兰州730030

出　　处：《中国肿瘤外科杂志》2023年第3期300-304,共5页Chinese Journal of Surgical Oncology

基　　金：国家自然科学基金项目(81670594);甘肃省科技重大专项(19ZD2WA001);甘肃省科技厅自然科学基金(21JR1RA129);甘肃省教育厅高校项目(2021B-026);兰州大学第二医院“萃英科技创新”计划(CY2020-BJ06)。

摘　　要：肠道微生物群具有多种生理功能,在宿主健康和肠道内环境稳定中起着关键作用。肿瘤的放疗会导致肠道菌群紊乱、免疫失调,引起急慢性炎症。同时,肠道菌群及其代谢物会影响放疗的效果和不良反应发生。现已发现应用益生菌、抗生素、粪便移植、菌群代谢物等改变宿主肠道菌群的方法具有预防和治疗放射性肠炎、增加放射敏感性及增强放疗效果的作用。文章就肠道菌群对肿瘤放疗的影响进行综述。Intestinal microbiota has a variety of physiological functions which plays a key role in host health and intestinal environmental stability.Radiotherapy of tumor leads to intestinal flora disorder,immune disorder,and acute and chronic inflammation.At the same time,intestinal flora and its metabolites affect the curative effect and the incidence of side effects of radiotherapy.It has been found that the application of probiotics,antibiotics,fecal transplantation,microbial metabolites and other methods to change the host intestinal flora can prevent and treat radiation enteritis,increase radiosensitivity and enhance the effect of radiotherapy.This article comprehensively expounds the current impact of intestinal flora on tumor radiotherapy.

关 键 词：肠道菌群 放疗 肿瘤 益生菌 抗生素 粪便移植 

分 类 号：R730.55[医药卫生—肿瘤]