The role of modern immunotherapy in metastatic urothelial cancer:mini review  

作　　者：Francesca Jackson-Spence Charlotte Toms Yu-Hsuen Yang Leo Jurascheck Julia Choy Lucy Flanders Bernadett Szabados Thomas Powles 

机构地区：[1]Barts Cancer Institute,Queen Mary University of London,London EC1M 6BQ,UK [2]Department of Medical Oncology,St Bartholomew’s Hospital,Barts Health NHS Trust,London EC1A 7BE,UK

出　　处：《Journal of Cancer Metastasis and Treatment》2022年第1期150-159,共10页癌症转移与治疗（英文版）

摘　　要：The approval of immune checkpoint inhibitors(ICIs)has changed the treatment landscape in many aspects of urothelial cancer(UC),in both non-muscle-invasive bladder cancer and muscle-invasive bladder cancer and has introduced the concept of long-term remission for some patients in the metastatic setting.Front-line chemotherapy remains superior at achieving initial control of disease compared to front-line immune therapy.However,long-term durable responses are limited by chemotherapy resistance.The maintenance approach,sequencing chemotherapy with ICIs,could be considered a best of both worlds approach,achieving initial control with chemotherapy,which is maintained in some individuals with avelumab.However,outcomes for patients with metastatic UC remain poor.There are three steps to improving outcomes for these patients;the first is to develop better drugs and combinations of therapies,the second is the development of novel biomarkers and techniques to better select patients for treatment,and the third area of development is to give the drugs in the most optimal setting.

关 键 词：Metastatic urothelial cancer bladder cancer immune therapy immune checkpoint inhibitors biomarkers 

分 类 号：R730.51[医药卫生—肿瘤]