寡核苷酸药物及其在口腔医学领域中应用的研究进展  

Oligonucleotide drugs and their progress in stomatology

作　　者：赵红 张志民[1] 邹馨颖 任飞龙 高爽[1] Zhao Hong;Zhang Zhimin;Zou Xinying;Ren Feilong;Gao Shuang(Department of Endodontics,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院牙体牙髓科,长春130021

出　　处：《中华口腔医学杂志》2023年第6期603-608,共6页Chinese Journal of Stomatology

基　　金：吉林省科技发展计划(20210101255JC)。

摘　　要：寡核苷酸药物具有靶向性、可修饰性和高生物安全性。近年研究表明,寡核苷酸可用于制作生物传感器、疫苗佐剂,并具有抑制牙槽骨吸收、促进颌骨和牙槽骨再生修复、抗肿瘤、破坏菌斑生物膜以及精准控制药物释放的功能。因此寡核苷酸在口腔医学领域具有广阔的应用前景。本文将从寡核苷酸的分类、作用机制以及其在口腔医学领域的研究现状进行综述,旨在为寡核苷酸的进一步研究和应用提供思路。Oligonucleotide drugs have the characteristics of targeting,modifiability and high biosafety.Recent studies have shown that oligonucleotide can be used to make biosensors,vaccine adjuvants,and has the functions of inhibiting alveolar bone resorption,promoting jaw and alveolar bone regeneration,anti-tumor,destroying plaque biofilm,and precise control of drug release.Therefore,it has a broad application prospect in the field of stomatology.This article reviews the classification,action mechanism and research status of oligonucleotide in stomatology.The aim is to provide ideas for further research and application of oligonucleotide.

关 键 词：寡核苷酸类 口腔医学 治疗 

分 类 号：R78[医药卫生—口腔医学]