血清IL-1β水平与老年患者抑郁症状交互作用对血脂代谢紊乱的影响  

The effect of the interaction between serum IL-1βlevel and depressive symptoms in elderly patients on the disorder of blood lipid metabolism

作　　者：靳小静[1] 韩彩莉 李卫[3] 陈莹[1] 张瑛琪[1] 苏冠丽[4] 汪艳丽 JIN Xiao-jing;HAN Cai-li;LI Wei;CHEN Ying;ZHANG Ying-qi;SU Guan-li;WANG Yan-li(Department of Emergency,the First Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;不详)

机构地区：[1]河北医科大学第一医院急诊科,河北石家庄050000 [2]河北医科大学第一医院医务处,河北石家庄050000 [3]河北医科大学第一医院胃肠外科,河北石家庄050000 [4]河北医科大学第一医院精神卫生科,河北石家庄050000

出　　处：《广东医学》2023年第6期735-740,共6页Guangdong Medical Journal

基　　金：河北省医学科学研究重点课题计划(20180213);河北医科大学第一医院“星火”青年科研项目(XH202013)。

摘　　要：目的探究血清白细胞介素-1β(IL-1β)水平与老年患者抑郁症状交互作用对其血脂代谢紊乱的影响。方法选取2018年1月至2021年1月的老年抑郁症患者115例(研究组),选取正常老年人共115例为对照组。对比分析两组受试者治疗前后空腹血脂水平、血清IL-1β水平以及抑郁症状,进一步分析血清IL-1β水平与抑郁症状的交互作用对患者血脂代谢紊乱的影响。结果治疗前,两组受试者空腹血脂水平、血清IL-1β水平以及抑郁症状差异有统计学意义(P<0.05)。治疗前后比较,研究组患者的空腹血脂水平、血清IL-1β水平以及抑郁症状差异有统计学意义(P<0.05),治疗6周后各指标均得到显著改善。Logistic多因素回归分析结果显示,高血清IL-1β水平以及抑郁症状均为患者血脂代谢紊乱的独立危险因素(P<0.05)。高血清IL-1β水平与抑郁症状对老年患者血脂代谢紊乱具有相加交互作用(P<0.05),高血清IL-1β水平和抑郁症状老年人发生血脂代谢紊乱的风险为低血清IL-1β水平且无抑郁症状老年人的8.274倍。结论高血清IL-1β水平以及抑郁症状均为患者血脂代谢紊乱的独立危险因素。高血清IL-1β水平与抑郁症状对老年患者血脂代谢紊乱具有相加交互作用。Objective To investigate the influence of the interaction between serum interleukin-1β(IL-1β)level and depressive symptoms in elderly patients on the disorder of blood lipid metabolism.Methods A total of 115 elderly depression patients(study group)from January 2018 to January 2021 were selected and compared with the normal control group(n=115).The fasting blood lipid,serum IL-1βand depressive symptoms of the two groups before and after treatment were compared and analyzed.The effect of the interaction between serum IL-1βand depressive symptoms on blood lipid metabolism disorders in patients was further analyzed.Results Before treatment,there were significant differences in fasting blood lipid,serum IL-1βand depressive symptoms between the two groups(P<0.05).Before and after treatment,there were significant differences in fasting blood lipid,serum IL-1βand depressive symptoms in the study group(P<0.05),and each index was significantly improved after 6 weeks of treatment.Logistic multivariate regression analysis showed that high serum IL-1βlevel and depressive symptoms were independent risk factors for dyslipidemia in patients(P<0.05).High serum IL-1βlevels and depressive symptoms had an additive interaction effect on dyslipidemia in elderly patients(P<0.05),and the risk of dyslipidemia in elderly with high serum IL-1βlevels and depressive symptoms was 8.274 times that of elderly with low serum IL-1βlevels and no depressive symptoms.Conclusion High serum IL-1βand depressive symptoms are independent risk factors for dyslipidemia in patients.High serum IL-1βand depressive symptoms have an additive interaction effect on dyslipidemia in elderly patients.

关 键 词：白细胞介素-1Β 抑郁症状 交互作用 血脂代谢紊乱 老年患者 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]