纳米金用于SPR传感器检测小分子的研究进展  

Research progress of gold nanoparticles for SPR biosensing of detection small molecules

作　　者：王浩 郑欣欣 孙宇航 陈子雷 颜朦朦 杨亲正[1] 杨焕新[1] WANG Hao;ZHENG Xinxin;SUN Yuhang;CHEN Zilei;YAN Mengmeng;YANG Qinzheng;YANG Huanxin(Faculty of Bioengineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China;Institution of Quality Standard and Testing Technology for Agro-Product,Shandong Academy of Agricultural Sciences,Jinan 250100,China)

机构地区：[1]齐鲁工业大学(山东省科学院)生物工程学部,山东济南250353 [2]山东省农业科学院农业质量标准与检测技术研究所,山东济南250100

出　　处：《齐鲁工业大学学报》2023年第3期37-44,共8页Journal of Qilu University of Technology

基　　金：国家自然科学基金(32102088,32172309);山东省农业科学院农业科技创新项目(CXGC2018E05,CXGC2021B14,CXGC2022E05)。

摘　　要：近年来,表面等离子体共振(Surface Plasmon Resonance,SPR)技术因具有可实时、动态监测SPR芯片上分子间相互作用的优点,而广泛应用于小分子传感检测领域。信号放大是小分子SPR传感器的重要研究内容,它决定小分子能否被检出及传感器灵敏度,因此信号放大技术对其发展非常重要。纳米金因其高电子密度、介电特性及易修饰等特性而用于多种传感器的信号放大。重点介绍近5年来纳米金在小分子SPR传感器方面的应用情况,旨在为小分子SPR传感器的进一步发展提供参考依据。In recent years,surface plasmon resonance(SPR)technology is widely used in detection the small molecule because it can monitor the intermolecular interaction on SPR chip in real time and dynamically.Signal amplification is an important research content of small molecule SPR sensor,which determines whether small molecule can be detected and sensor sensitivity.Therefore,signal amplification technology is necessary.Due to its high electron density,dielectric properties and easy modification,gold nanoparticles(Au NPs)is used in signal amplification of various sensors.This paper focuses on the application of Au NPs in small molecule SPR sensors in recent 5 years,aiming to provide reference for the further development of small molecule SPR sensors.

关 键 词：表面等离子体共振(SPR)传感器 小分子 纳米金 

分 类 号：TS207.3[轻工技术与工程—食品科学]