CT引导下经皮射频消融术治疗小肝癌的临床效果及对肝功能指标、并发症的影响  

Clinical effect of CT-guided percutaneous radiofrequency ablation in the treatment of small liver cancer and its influence on liver function indexes and complications

作　　者：张振伦 ZHANG Zhenlun(Department of Interventional,Jinan Fuda Cancer Hospital,Shandong Province,Jinan250000,China)

机构地区：[1]济南复大肿瘤医院介入科,山东济南250000

出　　处：《中国当代医药》2023年第18期74-77,共4页China Modern Medicine

基　　金：中国管理科学研究院教育科学研究所科教创新研究重点课题(KJCX14884)。

摘　　要：目的探讨CT引导下经皮射频消融术(RFA)及常规手术切除术对小肝癌患者的临床效果及对其肝功能指标、并发症发生情况的影响。方法选取2020年8月至2021年8月济南复大肿瘤医院收治的100例小肝癌患者作为研究对象,按随机数字表法将其分为研究组和对照组,每组50例,对照组实施常规腹腔镜下肝切除术,研究组经CT引导实施RFA治疗,比较两组患者治疗前后的谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清总胆红素(TBil)、甲胎蛋白异质体3(AFP-L3)、高尔基体蛋白73(GP73)以及磷脂酰基醇蛋白聚糖3(GPC-3)。统计两组患者经不同方式治疗后并发症发生情况。结果研究组治疗后的ALT、AST、TBil、AFP-13、GP37、GPC-3均低于对照组,差异有统计学意义(P<0.05),该组患者术后并发症总发生率10.00%(5/50)低于对照组24.00%(12/50),差异有统计学意义(P<0.05)。结论经CT引导下的RFA术治疗,可显著改善患者的肝功能指标及血清相关指标水平,患者术后发生严重并发症的风险更低,其临床价值较高,建议可进一步推广应用。Objective To explore the clinical effects of CT guided percutaneous radiofrequency ablation(RFA)and conventional surgical resection on small liver cancer patients,as well as their impact on liver function indicators and complications.Methods A total of 100 patients with small liver cancer admitted to Jinan Fuda Cancer Hospital from August 2020 to August 2021 were selected as the study subjects,they were randomly divided into a study group and a control group using a random number table method,with 50 patients in each group.The control group underwent routine laparoscopic liver resection,while the study group underwent RFA treatment under CT guidance,The alanine transaminase(ALT),aspartate transaminase(AST),serum total bilirubin(TBil),alpha fetoprotein heterogeneity 3(AFP-L3),Golgi protein 73(GP73),phosphatidyl glycoglycan 3(GPC-3)before and after treatment were compared between the two groups,and the complications of the two groups after different treatment were counted.Results After treatment,the ALT,AST,TBil,AFP-13,GP37,and GPC-3 levels in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative complications in this group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion CT guided RFA surgery can significantly improve liver function indicators and serum related indicators in patients,reduce the risk of serious complications after surgery,and have high clinical value.It is recommended to further promote its application.

关 键 词：小肝癌 CT引导下经皮射频消融术 常规手术 疗效比较 肝功能 并发症 

分 类 号：R734[医药卫生—肿瘤]