YAP及Src在胃癌组织中的表达及临床意义  

Expression and clinical significance of YAP and Src in gastric cancer tissues

作　　者：蔡甲慧 陶飞[2] CAI Jiahui;TAO Fei(Qinghai University,Qinghai Xining 810016,China;Qinghai Provincial People's Hospital,Qinghai Xining 810007,China)

机构地区：[1]青海大学,青海西宁810016 [2]青海省人民医院,青海西宁810007

出　　处：《现代肿瘤医学》2023年第13期2475-2480,共6页Journal of Modern Oncology

基　　金：青海省卫健委医药卫生指导性计划课题(编号:2021-wjzdx-02)。

摘　　要：目的:探讨胃癌患者肿瘤及癌旁组织中YAP、Src的表达差异,分析肿瘤组织中YAP、Src表达与临床病理特征的关系和二者表达的相关性。方法:收集青海省人民医院2020-2022年确诊的胃癌患者61例,从中采集肿瘤组织61例、癌旁组织40例,应用免疫组织化学方法检测肿瘤组织及癌旁组织中YAP、Src的表达,分析二者的表达及相关性,并结合临床病理学资料进行统计学分析。结果:肿瘤组织中YAP、Src表达的阳性率(95.1%、83.6%)明显高于癌旁组织(30.0%、27.5%)(均P<0.01)。肿瘤组织中YAP的表达与患者的年龄、民族、分化程度、浸润深度、脉管侵犯、神经侵犯、Ki67阳性指数相关(均P<0.05);Src的表达与患者民族、肿瘤部位、浸润深度、神经侵犯、Ki67阳性指数、HER-2状态相关(均P<0.05);肿瘤组织中YAP、Src表达呈正相关(r=0.514,P<0.01)。结论:胃癌患者肿瘤组织中YAP、Src处于过度表达状态,YAP与Src的表达呈正相关;二者高表达与胃癌患者部分不良临床病理特征密切相关。Objective:To investigate the differences in the expression of YAP and Src in tumor and adjacent tissues of patients with gastric cancer,and to analyze the relationship between the expression of YAP and Src in tumor tissues and clinicopathological features,as well as the correlation between the YAP expression and Src expression.Methods:Sixty-one patients with gastric cancer diagnosed in Qinghai Provincial People's Hospital from 2020 to 2022 were collected,and 61 cases of tumor tissues and 40 cases of adjacent tissues were collected.The expressions of YAP and Src in tumor tissues and adjacent tissues were detected by immunohistochemical method,and their expressions and correlations were analyzed.Their expressions were combined with clinicopathological data for statistical analysis.Results:The positive rates of YAP and Src expression in tumor tissues(95.1%,83.6%)were significantly higher than those in adjacent tissues(30.0%,27.5%)(all P<0.01).The expression of YAP in tumor tissues was related to the age,nationality,differentiation,infiltration depth,vascular invasion,nerve invasion and Ki67 positive index(all P<0.05).The expression of Src was correlated with nationality,tumor site,infiltration depth,nerve invasion,Ki67 positive index and HER-2 status(all P<0.05).The expression of YAP and Src in tumor tissues was positively correlated(r=0.514,P<0.01).Conclusion:YAP and Src are over-expressed in tumor tissues of patients with gastric cancer,and the expression of YAP and Src is positively correlated.The high expression of both of them is closely related to some adverse clinicopathological features of gastric cancer patients.

关 键 词：胃癌 YAP SRC 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]