m^(6)A-RNA甲基化YTHDF1结合蛋白在胶质瘤中作用的研究进展  

Research progress of m^(6)A-RNA methylated YTHDF1 binding protein in glioma

作　　者：朱琳 于涛 郑法康 龚海东 ZHU Lin;YU Tao;ZHENG Fakang;GONG Haidong(Department of Neurosurgery,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Mudanjiang 157011,China)

机构地区：[1]牡丹江医学院附属红旗医院神经外科,黑龙江牡丹江157011

出　　处：《现代肿瘤医学》2023年第13期2512-2518,共7页Journal of Modern Oncology

基　　金：黑龙江省省属基本科研业务费(编号:2020-KYYWF-0751)。

摘　　要：胶质瘤是最常见的原发性颅内恶性肿瘤,占颅脑恶性肿瘤的45%,目前临床对胶质瘤主要采取手术治疗,但其浸润生长、复发率高等特性导致其预后较差。目前RNA修饰尤其是m^(6)A甲基化是肿瘤研究的热点,随着高通量测序方法的不断进步,对转录表观遗传学的研究也在不断的深入。m^(6)A(N6-甲基腺苷)甲基化是真核细胞中最多见的修饰方式,尤其在信使RNA(message ribonucleic acid,mRNA)中。m^(6)A甲基化可以从RNA的转录、核输出、翻译、衰变等诸多方面影响RNA的代谢,参与生物体的胚胎发育,昼夜节律,应激反应,甚至肿瘤的发生,而YTHDF1是脑胶质瘤中表达最高的一种m^(6)A甲基化的识别蛋白,能够识别并诱导目标的翻译。本文将结合近期的研究进展,重点对m^(6)A结合蛋白YTHDF1的作用方式、生物学特性、胶质瘤的发展、现有的潜在影响等方面进行综述。Glioma is the most common primary intracranial malignant tumor,accounting for 45%of brain tumors.Currently,gliomas are mainly treated by surgery,but their infiltration growth and high recurrence rate lead to poor prognosis.At present,RNA modification,especially m^(6)A methylation,is a hot spot in tumor research.With the continuous progress of high-throughput sequencing methods,the research on transcriptional epigenetics is also deepening.m^(6)A(N 6-methyladenosine)methylation is the most common modification in eukaryotic cells,especially in messenger RNA(message ribonucleic acid,mRNA).m^(6)A methylation can affect the metabolism of RNA from many aspects such as RNA transcription,nuclear export,translation,decay,etc.It participates in the embryonic development of organisms,circadian rhythm,stress response,and even the occurrence of tumors.YTHDF1,the highest expression of m^(6)A methylated recognition protein in glioma can recognize and induce target translation.This article will combine recent research progress,focusing on the mode of action,biological characteristics,development of gliomas,and existing potential effects of the m^(6)A binding protein YTHDF1.

关 键 词：YTHDF1 胶质瘤 m^(6)A甲基化 肿瘤干细胞 

分 类 号：R739.41[医药卫生—肿瘤]