DNA异常甲基化在前列腺癌发生发展及诊疗中的研究进展  

Research progress on abnormal DNA methylation in the occurrence,development,diagnosis and treatment of prostate cancer

作　　者：顾君 陈振杰 何泽喜 王海峰 吴海超 林嘉伟 丁明霞[1] GU Jun;CHEN Zhenjie;HE Zexi;WANG Haifeng;WU Haichao;LIN Jiawei;DING Mingxia(Department of Urology,the Second Affiliated Hospital of Kunming Medical University,Yunnan Institute of Urology,Yunnan Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南省泌尿外科研究所,云南昆明650101

出　　处：《现代肿瘤医学》2023年第13期2541-2545,共5页Journal of Modern Oncology

基　　金：云南省应用基础研究-昆医联合专项[编号:2019FE001(-226)];云南省高校创新团队建设项目(编号:云教[2019]58号);云南省“万人计划”名医专项、云南省领军人才培养项目(编号:L-2018009)。

摘　　要：前列腺癌是全球男性常发的恶性肿瘤之一。近年来研究发现前列腺癌的发生发展很大程度上是由表观遗传修饰所驱动的,其中最重要的当属DNA异常甲基化。DNA启动子的异常甲基化会造成基因的异常表达,从而调控着前列腺癌的发生发展过程。此外,目前前列腺癌的诊断仍然依靠侵入性的前列腺穿刺活检,而基于DNA异常甲基化的无创性液体活检有望成为未来前列腺癌分子诊断的发展趋势,同时也为前列腺癌提供了新的治疗靶标。本文就DNA甲基化在前列腺癌发生发展、早期诊断、预后评估以及治疗中的研究进展进行综述。Prostate cancer is one of the most common men malignant tumor in the world.Recent studies have found that the occurrence and development of prostate cancer is largely driven by epigenetic modifications,among which the most important is abnormal DNA methylation.Abnormal methylation of DNA promoters can lead to abnormal gene expression and regulate the development of prostate cancer.In addition,the diagnosis of prostate cancer still relies on invasive needle biopsy of prostate now,while non-invasive liquid biopsy based on abnormal DNA methylation is expected to become the development trend of molecular diagnosis of prostate cancer in the future.It also provides a new therapeutic target for prostate cancer.In this article,we review the research progress of DNA methylation in the development,progression,early diagnosis,prognostic evaluation and treatment of prostate cancer.

关 键 词：DNA甲基化 表观遗传学 前列腺癌 诊断 治疗 

分 类 号：R737.25[医药卫生—肿瘤]