早期脑梗死应用丁苯酞氯化钠注射液治疗的临床效果探讨  

Clinical effect of butylphthalide and sodium chloride injection on early cerebral infarction

作　　者：段丽[1] 丁姝月[1] DUAN Li;DING Shu-yue(Department Two of Neurology,Inner Mongolia Bayannur Hospital,Bayannur 015000,China)

机构地区：[1]巴彦淖尔市医院神经内二科,015000

出　　处：《中国实用医药》2023年第11期6-9,共4页China Practical Medicine

摘　　要：目的探讨早期脑梗死患者应用丁苯酞氯化钠注射液治疗的临床效果。方法68例早期脑梗死患者作为研究对象,按照治疗方式不同分为对照组和研究组,每组34例。两组患者住院后均给予常规治疗,对照组给予阿司匹林联合氯吡格雷治疗,研究组在对照组基础上联合丁苯酞氯化钠注射液治疗。对比两组患者治疗效果,治疗前后血粘度[全血高切粘度(HSV)、全血低切粘度(LSV)、血浆粘度(PSV)],治疗前后美国国立卫生研究院卒中量表(NIHSS)、日常生活活动能力量表(ADL)评分。结果研究组治疗显效16例(47.06%),有效16例(47.06%),无效2例(5.88%);对照组治疗显效12例(35.29%),有效12例(35.29%),无效10例(29.41%)。研究组治疗总有效率94.12%(32/34)高于对照组的70.59%(24/34),差异具有统计学意义(P<0.05)。治疗前,两组患者的HSV、PSV、LSV对比差异均无统计学意义(P>0.05);治疗后,研究组患者的HSV、PSV、LSV分别为(4.05±2.34)、(1.25±0.73)、(8.01±2.01)mPa·s,均明显低于对照组的(6.04±2.46)、(2.09±0.84)、(10.78±2.14)mPa·s,差异具有统计学意义(P<0.05)。治疗前,两组患者的NIHSS、ADL评分对比差异均无统计学意义(P>0.05);治疗后6个月,研究组患者的NIHSS评分(6.52±1.42)分明显低于对照组的(9.13±2.73)分,ADL评分(67.43±7.52)分明显高于对照组的(45.63±9.02)分,差异具有统计学意义(P<0.05)。结论早期脑梗死患者应用丁苯酞氯化钠注射液治疗的临床效果显著,能有效降低患者神经功能损伤,提高生活自理能力,改善患者预后,具有临床推广价值。Objective To discuss the clinical effect of butylphthalide and sodium chloride injection on early cerebral infarction.Methods A total of 68 patients with early cerebral infarction were divided into control group and research group according to different treatment methods,with 34 cases in each group.Both groups were given conventional treatment after hospitalization.The control group was treated with aspirin and clopidogrel,and the research group was combined with butylphthalide and sodium chloride injection on the basis of the control group.Both groups were compared in terms of therapeutic effect,blood viscosity[high shear viscosity(HSV),low shear viscosity(LSV),plasma viscosity(PSV)]before and after treatment,and scores of National Institutes of Health Stroke Scale(NIHSS)and Activities of Daily Living Scale(ADL)before and after treatment.Results In the research group,16 cases(47.06%)were significantly effective,16 cases(47.06%)were effective,and 2 cases(5.88%)were ineffective;in the control group,12 cases(35.29%)were significantly effective,12 cases(35.29%)were effective,and 10 cases(29.41%)were ineffective.The total effective rate of the research group was 94.12%(32/34),which was higher than that of 70.59%(24/34)of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in HSV,PSV and LSV between the two groups(P>0.05).After treatment,the HSV,PSV and LSV were(4.05±2.34),(1.25±0.73)and(8.01±2.01)mPa·s in the research group,which were significantly lower than those of(6.04±2.46),(2.09±0.84)and(10.78±2.14)mPa·s in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in NIHSS score and ADL score between the two groups(P>0.05).6 months after treatment,the NIHSS score of(6.52±1.42)points in the research group was significantly lower than that of(9.13±2.73)points in the control group,and the ADL score of(67.43±7.52)points in the

关 键 词：氯吡格雷 丁苯酞氯化钠注射液 脑梗死 临床效果 

分 类 号：R743.33[医药卫生—神经病学与精神病学]