电休克治疗对重度抑郁症患者脑功能网络的影响研究  

Effect of electroconvulsive therapy on brain functional network in major depressive disorder

作　　者：田树香 徐桂芝[1,2,3] 杨新生[1,2,3] Paul B Fitzgerald Alan Wang TIAN Shuxiang;XU Guizhi;YANG Xinsheng;Paul B Fitzgerald;Alan Wang(Key Laboratory of Bioelectromagnetic and Neural Engineering of Hebei Province,Hebei University of Technology,Tianjin 300401,P.R.China;Tianjin Key Laboratory of Bioelectricity and Intelligent Health,Hebei University of Technology,Tianjin 300401,P.R.China;State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebei University of Technology,Tianjin 300130,P.R.China;National Institute on Drug Dependence,Peking University,Beijing 100191,P.R.China;School of Medicine and Psychology,The Australian National University,Canberra,Australian Capital Territory 2601,Australia;Auckland Bioengineering Institute,The University of Auckland,Auckland 1010,New Zealand;Faculty of Medical and Health Sciences,The University of Auckland,Auckland 1023,New Zealand;Centre for Brain Research,The University of Auckland,Auckland 1042,New Zealand)

机构地区：[1]河北工业大学河北省生物电磁与神经工程重点实验室,天津300401 [2]河北工业大学天津市生物电工与智能健康重点实验室,天津300401 [3]河北工业大学省部共建电工装备可靠性与智能化国家重点实验室,天津300130 [4]北京大学中国药物依赖性研究所,北京100191 [5]School of Medicine and Psychology,The Australian National University,Canberra,Australian Capital Territory 2601,Australia [6]Auckland Bioengineering Institute,The University of Auckland,Auckland 1010,New Zealand [7]Faculty of Medical and Health Sciences,The University of Auckland,Auckland 1023,New Zealand [8]Centre for Brain Research,The University of Auckland,Auckland 1042,New Zealand

出　　处：《生物医学工程学杂志》2023年第3期426-433,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点项目(51737003);河北工业大学海外联合培养基金项目(2017HW007);中国国家留学基金委项目(201806700011)。

摘　　要：电休克治疗(ECT)是一种能够对重度抑郁症(MDD)进行高效神经调节的干预技术,但其抗抑郁作用机制尚不明确。本文通过记录19例MDD患者在ECT前后的静息状态脑电(RS-EEG),从多角度分析了ECT对MDD患者静息态脑功能网络的调制作用:利用Welch算法估算自发脑电活动功率谱密度(PSD);基于虚部相干(iCoh)构建脑功能网络并计算功能连通性;利用最小生成树理论探究脑功能网络的拓扑结构特征。结果表明,MDD患者多个节律PSD、功能连通性和拓扑结构在ECT后发生了显著变化。本文研究结果揭示了ECT对MDD患者大脑活动的作用,对MDD的临床治疗和机制解析具有重要参考作用。Electroconvulsive therapy(ECT)is an interventional technique capable of highly effective neuromodulation in major depressive disorder(MDD),but its antidepressant mechanism remains unclear.By recording the resting-state electroencephalogram(RS-EEG)of 19 MDD patients before and after ECT,we analyzed the modulation effect of ECT on the resting-state brain functional network of MDD patients from multiple perspectives:estimating spontaneous EEG activity power spectral density(PSD)using Welch algorithm;constructing brain functional network based on imaginary part coherence(iCoh)and calculate functional connectivity;using minimum spanning tree theory to explore the topological characteristics of brain functional network.The results show that PSD,functional connectivity,and topology in multiple frequency bands were significantly changed after ECT in MDD patients.The results of this study reveal that ECT changes the brain activity of MDD patients,which provides an important reference in the clinical treatment and mechanism analysis of MDD.

关 键 词：重度抑郁症 电休克治疗 静息态脑电 脑功能网络 最小生成树 

分 类 号：R749.4[医药卫生—神经病学与精神病学]