基底节区高血压脑出血患者软通道穿刺血肿腔引流术后并发癫痫的影响因素  

Influencing factors for epilepsy after soft channel puncture of hematoma cavity drainage in patients with hypertensive intracerebral hemorrhage in basal ganglia

作　　者：隋长百 谢基彦 刘英 赵志 王鹏 SUI Changbai;XIE Jiyan;LIU Ying;ZHAO Zhi;WANG Peng(Yantaishan Hospital of Yantai,Yantai 264003,China;Beihai Hospital of Yantai,Yantai 265701,China)

机构地区：[1]烟台市烟台山医院,山东烟台264003 [2]烟台市北海医院,山东烟台265701

出　　处：《中国实用神经疾病杂志》2023年第7期830-835,共6页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析基底节区高血压脑出血(HICH)患者软通道穿刺血肿腔引流术后并发癫痫的影响因素。方法选取2019-01—2022-04采用软通道穿刺血肿腔引流术治疗的150例基底节区HICH患者为研究对象,统计所有患者术后2周时癫痫发生情况,分为发生癫痫组与未发生癫痫组,统计2组患者的基线资料,经单因素及多因素分析基底节区HICH患者软通道穿刺血肿腔术后并发癫痫的影响因素。结果发生癫痫组与未发生癫痫组患者的高血压病程、入院时美国国立卫生研究院卒中量表(NIHSS)评分、术前血清神经元特异性烯醇化酶(NSE)、术前血清肿瘤坏死因子α(TNF-α)、术前血清白细胞介素6(IL-6)水平比较差异有统计学意义(P<0.05),组间其他资料比较差异无统计学意义(P>0.05);回归分析显示,高血压病程长、入院时NIHSS评分高及术前血清NSE、TNF-α、IL-6水平升高等因素是基底节区HICH患者软通道穿刺血肿腔术后并发癫痫的影响因素(OR>1,P<0.05)。结论HICH患者软通道穿刺血肿腔引流术后有较高的并发癫痫风险,可能与高血压病程长、入院时NIHSS评分高及术前血清NSE、TNF-α、IL-6水平过表达有关。Objective To analyze the influencing factors of epilepsy after soft channel puncture of hematoma cavity drainage in patients with basal ganglia hypertensive intracerebral hemorrhage(HICH).Methods Totally 150 patients with HICH in basal ganglia treated by soft channel puncture from Jan.2019 to Apr.2022 were selected as the research objects.The incidence of epilepsy in all patients at 2 weeks after operation was counted.According to the results,they were divided into the occurrence epilepsy group and the non-occurrence epilepsy group.The baseline data of the two groups were counted in detail.The influencing factors of epilepsy after soft channel puncture of hema⁃toma cavity in patients with HICH in basal ganglia were found out by univariate and multivariate analysis.Results There are significant differences in the course of hypertension,National Institutes of Health stroke scale(NIHSS)score at admission,preoperative serum neuron specific enolase(NSE),preoperative serum tumor necrosis factorα(TNF-α),andserum levels of interleukin-6(IL-6)between these two groups(P<0.05).No significant difference was found in other data between groups(P>0.05);the results of regression analysis showed that the long course of hyper⁃tension,the high NIHSS score at admission,and the high levels of the preoperative serum NSE,TNF-α,and IL-6 are the influencing factors of epilepsy after soft channel puncture of hematoma cavity in patients with HICH in basal gan⁃glia(OR>1,P<0.05).Conclusion HICH patients have a higher risk of epilepsy after soft channel puncture of hema⁃toma cavity drainage,which may be related to the long course of hypertension,high NIHSS score at admission,preop⁃erative serum NSE and TNF-α,IL-6 level overexpression.

关 键 词：高血压脑出血 基底节区 软通道穿刺血肿腔引流术 癫痫 影响因素 

分 类 号：R743.34[医药卫生—神经病学与精神病学]