肝硬化门静脉血栓的危险因素和预测模型分析  

Analysis of risk factors and prediction model of portal vein thrombosis in liver cirrhosis

作　　者：于亭亭 王存凯 王鼎鑫[1] 张佩彦 赵爽[1] 朱萌然 孙延召 刘洪娜[1] 刘红玉 李月芹[1] 白云[1] Yu Tingting;Wang Cunkai;Wang Dingxin;Zhang Peiyan;Zhao Shuang;Zhu Mengran;Sun Yanzhao;Liu Hongna;Liu Hongyu;Li Yueqin;Bai Yun(Department of Geriatric Gastroenterology,Hebei General Hospital,Shijiazhuang 050051,China;Graduate School of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北省人民医院老年消化科,石家庄050051 [2]河北北方学院研究生院,张家口075000

出　　处：《中国临床实用医学》2023年第2期35-40,共6页China Clinical Practical Medicine

基　　金：河北省政府资助医学人才项目(20220017)。

摘　　要：目的分析肝硬化门静脉血栓(PVT)的独立危险因素。方法本研究为病例对照研究,选取2016年7月至2021年7月河北省人民医院老年消化科收治的158例肝硬化患者,男93例,女65例,年龄(58.21±1.30)岁,年龄范围为41~86岁。根据是否有PVT将患者分为PVT组(n=51)和非PVT组(n=107)。收集两组患者的临床资料、实验室检查、影像学资料。经多因素二元logistic回归分析筛选出独立危险因素,绘制受试者工作特征曲线,计算曲线下面积以评估危险因素及联合预测模型对肝硬化患者PVT形成的预测效能。结果年龄、自身免疫性肝硬化病因、淋巴细胞计数、D-二聚体、门静脉宽度、脾脏厚度是肝硬化合并PVT形成的独立危险因素。联合模型对肝硬化PVT的预测价值更高。结论联合预测模型对肝硬化患者PVT的预测价值较高,对临床工作有一定指导意义。Objective Analyse the independent risk factors of portal vein thrombosis(PVT)in iver cirrhosis.Methods This study was a case-control study.A total of 158 patients with cirrhosis,including 93 males and 65 females,aged(58.21±1.30)years old,ranging from 41 to 86 years old,were selected from the department of geriatric gastroenterology from Hebei General Hospital from July 2016 to July 2021.All patients were divided into PVT group(n=51)and non-PVT group(n=107)according to the presence or absence of PVT.The clinical data,laboratory examination and imaging data of the two groups were collected.Independent risk factors were screened out by multivariate binary logistic regression analysis,the receiver operating characteristic curve was drawn,and the area under the curve was calculated to evaluate predictive efficacy of risk factors and combined prediction models for PVT formation in patients with liver cirrhosis.Results Age,etiology of autoimmune cirrhosis,lymphocyte count,D-dimer,portal vein width and spleen thickness were independent risk factors for cirrhosis complicated with portal vein thrombosis.The combined model had a higher predictive value for PVT of cirrhosis.Conclusions The combined prediction model has high predictive value for PVT in patients with cirrhosis and has certain guiding significance for clinical work.

关 键 词：肝硬化 门静脉血栓 淋巴细胞计数 D-二聚体 门静脉宽度 脾脏厚度 联合预测模型 

分 类 号：R575.2[医药卫生—消化系统]