中性粒细胞DNA甲基化对牙周炎的影响及生物信息学研究进展  

Effects of neutrophil DNA methylation on periodontitis and research progress in bioinformatics

作　　者：李萌萌[1] 赵博[1] 李荣华[1] Li Mengmeng;Zhao Bo;Li Ronghua(Department of Stomatology,Tianjin First Central Hospital,Tianjin 300191,China)

机构地区：[1]天津市第一中心医院口腔科,天津300191

出　　处：《国际生物医学工程杂志》2023年第2期180-184,共5页International Journal of Biomedical Engineering

摘　　要：牙周炎是导致牙周结缔组织破坏及牙槽骨吸收的慢性感染性疾病,其发病率广泛,严重危害了广大患者的口腔及全身健康。宿主免疫炎症反应在牙周炎组织破坏中起了主要作用。多形核中性粒细胞(PMNs)作为牙周组织中重要的免疫细胞成分之一,可通过释放促炎因子,引发宿主免疫炎症反应,进而导致牙周炎的发生。DNA甲基化可以通过调节基因表达而影响免疫细胞的功能发挥。生物信息学技术可以通过分析公共数据库中牙周炎患者与健康人群牙周组织基因表达谱及DNA甲基化数据,挖掘关键的PMNs DNA甲基化基因,阐释该基因对于牙周炎病理进展的影响,从而为牙周炎的治疗提供新思路。Periodontitis is a chronic infectious disease leading to periodontal connective tissue destruction and alveolar bone resorption,which is widely prevalent and seriously endangers the oral and systemic health of a wide range of patients.The host immune inflammatory response plays a major role in the tissue destruction of periodontitis.Polymorphonuclear neutrophils(PMNs),as one of the important immune cell components in periodontal tissues,can trigger the host immune inflammatory response through the release of pro-inflammatory factors,which in turn leads to periodontitis.DNA methylation can influence the function of immune cells by regulating gene expression.Bioinformatics technology can provide new ideas for the treatment of periodontitis by analyzing the gene expression profiles and DNA methylation data of periodontal tissues from public databases of periodontitis patients and healthy populations,uncovering key DNA methylation genes of PMNs,and elucidating the influence of these genes on the pathological progression of periodontitis.

关 键 词：牙周炎 多形核中心粒细胞 DNA甲基化 生物信息学技术 

分 类 号：R781.42[医药卫生—口腔医学] Q811.4[医药卫生—临床医学]