重症监护病房获得性肌无力的发病机制研究现状及展望  

Intensive care unit acquired weakness:current status and prospects of studies on pathogenesis

作　　者：李璐 潘广华 俞立强[1] 方琪[1] LI Lu;PAN Guanghua;YU Liqiang;FANG Qi(The First Hospital of Soochow University,Suzhou,Jiangsu 215006,China;Weihai Municipal Hospital,Weihai,Shandong 264200,China)

机构地区：[1]苏州大学附属第一医院,江苏苏州215006 [2]威海市立医院,山东威海264200

出　　处：《国际神经病学神经外科学杂志》2023年第2期62-66,共5页Journal of International Neurology and Neurosurgery

基　　金：苏州市引进临床医学团队项目:首都医科大学宣武医院王陇德院士团队(SZYJTD201802)。

摘　　要：重症监护病房获得性肌无力(intensive care unit acquired weakness,ICUAW)是重症监护病房患者出现的进行性全身肢体无力,且除危重病本身外无其他原因可解释的一组临床综合征,主要表现为神经肌肉功能障碍。ICUAW的发病机制涉及中枢、周围神经系统和肌纤维内复杂的功能、结构改变,但尚未完全明确。该文综述了目前关于ICUAW的潜在发病机制,以期对ICUAW的诊治提供新思路。Intensive care unit acquired weakness(ICUAW) is a group of clinical syndromes characterized by progressive systemic limb weakness in patients in the intensive care unit,with no other reason to explain it except for critically ill individuals.The main manifestation is neuromuscular dysfunction.The pathogenesis of ICUAW involves complex functional and structural changes in the central,peripheral nervous system and muscle fibers,but it has not yet been fully understood.This article reviews the potential pathogenesis of ICUAW at present,in order to provide new ideas for the diagnosis and treatment of ICUAW.

关 键 词：重症监护病房获得性肌无力 危重症多发性神经病 危重症性肌病 发病机制 

分 类 号：R741[医药卫生—神经病学与精神病学]