胶质瘤术中快速病理精准诊断的研究进展  

Research advances in rapid and accurate intraoperative pathological diagnosis of glioma

作　　者：张小宁 吉宏明[2] 王春红[2] ZHANG Xiaoning;JI Hongming;WANG Chunhong(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030001,China;The Fifth Hospital of Shanxi Medical University/Shanxi Provincial People's Hospital,Taiyuan,Shanxi 030012,China)

机构地区：[1]山西医科大学第五临床医学院,山西太原030001 [2]山西医科大学第五医院/山西省人民医院,山西太原030012

出　　处：《国际神经病学神经外科学杂志》2023年第2期71-76,共6页Journal of International Neurology and Neurosurgery

基　　金：山西省人民医院省级专项配套经费科研项目(sj20019023);山西省基础研究计划(202103021224380,202103021224386)。

摘　　要：胶质瘤是最常见的中枢神经系统恶性肿瘤,手术切除是临床治疗胶质瘤最成熟、治愈率最高的方法。在术中术者面临的主要难题是尽可能保留功能的前提下彻底切除病灶,而不断发展的术中快速病理诊断技术给予了术者极大帮助,可以使术者在术中对肿瘤的性质和类型、浸润程度、范围及手术切缘等做出快速、精确的判断,从而在第一时间为患者制定更科学、更准确的治疗方案。该文概述了目前各类术中快速病理诊断技术的主要特点,对胶质瘤术中快速病理精准诊断的研究进展做一综述。Glioma is the most common malignant tumor of the central nervous system,and surgical resection is the most mature therapeutic method for glioma and shows the highest cure rate in clinical practice.The main difficulty faced by the surgeon during the surgery is to completely remove the lesion under the premise of preserving the function as much as possible,and the development of rapid intraoperative pathological diagnosis greatly helps and enables the surgeon to make a rapid and accurate judgment on the nature,type,invasion,extent,and resection margin of tumor during surgery,so as to formulate a more scientific and precise treatment regimen for the patient at the first time.This article summarizes the main characteristics of various techniques for rapid intraoperative pathological diagnosis and reviews the research advances in their application in rapid and accurate intraoperative pathological diagnosis for glioma surgery.

关 键 词：胶质瘤 术中快速病理诊断 冷冻切片 快速免疫组化 超声波快速切片 术中细胞学 质谱成像 拉曼光谱 分子诊断 

分 类 号：R739.41[医药卫生—肿瘤]