Zataria multiflora and its constituent,carvacrol,counteract sepsis-induced aortic and cardiac toxicity in rat:Involvement of nitric oxide and oxidative stress  

作　　者：Mahmoud Hosseini Zohreh Arab Farimah Beheshti Akbar Anaeigoudari Farzaneh Shakeri Arezoo Rajabian 

机构地区：[1]Psychiatry and Behavioral Sciences Research Center,Mashhad University of Medical Sciences,Mashhad,Iran [2]Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran [3]Neuroscience Research Center,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran [4]Department of Physiology,School of Paramedical Sciences,Torbat Heydariyeh University of Medical Sciences,Torbat Heydariyeh,Iran [5]Department of Physiology,School of Medicine,Jiroft University of Medical Sciences,Jiroft,Iran [6]Natural Products and Medicinal Plants Research Center,North Khorasan University of Medical Sciences,Bojnurd,Iran [7]Department of Physiology and Pharmacology,School of Medicine,North Khorasan University of Medical Sciences,Bojnurd,Iran [8]Department of Internal Medicine,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran

出　　处：《Animal Models and Experimental Medicine》2023年第3期221-229,共9页动物模型与实验医学（英文）

基　　金：All experimental procedures pursued the relevant guidelines and regulations of the National Institute of Health Guide for the Care and Use of Laboratory Animals(NIH Publications No.80-23,revised 1978);were approved by the Ethics Committee of Mashhad University of Medical Sciences,Iran(IR.MUMS.fm.REC.1397.139).

摘　　要：Background:Zataria multiflora and carvacrol showed various pharmacological prop-erties including anti-inflammatory and anti-oxidant effects.However,up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac injury.Thus,this study aimed to investigate the effects of Z.multiflora and carvacrol on nitric oxide(NO)and oxidative stress indicators in lipopolysaccharide(LPS)-induced aortic and cardiac injury.Methods:Adult male Wistar rats were assigned to:Control,lipopolysaccharide(LPS)(1 mg/kg,intraperitoneal(i.p.)),and Z.multiflora hydro-ethanolic extract(ZME,50–200 mg/kg,oral)-and carvacrol(25–100 mg/kg,oral)-treated groups.LPS was in-jected daily for 14 days.Treatment with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS administration.At the end of the study,the levels of malondialdehyde(MDA),NO,thiols,and antioxidant enzymes were evaluated.Results:Our findings showed a significant reduction in the levels of superoxide dis-mutase(SOD),catalase(CAT),and thiols in the LPS group,which were restored by ZME and carvacrol.Furthermore,ZME and carvacrol decreased MDA and NO in car-diac and aortic tissues of LPS-injected rats.Conclusions:The results suggest protective effects of ZME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO pro-duction.However,additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.

关 键 词：CARVACROL LIPOPOLYSACCHARIDE nitric oxide oxidative injury SEPSIS Z.multiflora 

分 类 号：R285.5[医药卫生—中药学]