注射用七叶皂苷钠联合超早期小骨窗脑出血清除术治疗高血压脑出血的有效性及安全性  

Efficacy and Safety of Sodium Aescinate Injection Combined with Ultra-Early Clearance of Small Bone Window Intracerebral Hemorrhage in the Treatment of Hypertensive Intracerebral Hemorrhage

作　　者：奚再兴[1] 刘飞皎[1] 孙含蓄[1] XI Zaixing;LIU Feijiao;SUN Hanxu(Department of Neurosurgery,the First People’s Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院神经外科,河南南阳473000

出　　处：《河南医学研究》2023年第12期2202-2206,共5页Henan Medical Research

摘　　要：目的探讨注射用七叶皂苷钠联合超早期小骨窗脑出血清除术治疗高血压脑出血(HICH)的有效性及安全性。方法选取2021年8月至2022年7月南阳市第一人民医院收治的86例HICH患者,以随机数字表法分成研究组与对照组,各43例。对照组接受超早期小骨窗脑出血清除术治疗,研究组接受注射用七叶皂苷钠联合超早期小骨窗脑出血清除术治疗。比较两组临床疗效、神经损伤标志物水平、炎症因子水平及安全性。结果研究组治疗总有效率(90.70%)高于对照组(72.09%)(P<0.05);两组治疗后神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)、胶质纤维酸性蛋白(GFAP)水平降低(P<0.05),研究组水平低于对照组(P<0.05);两组治疗后白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平降低(P<0.05),研究组水平低于对照组(P<0.05);研究组不良反应发生率(11.63%)与对照组(6.98%)比较,差异无统计学意义(P>0.05)。结论注射用七叶皂苷钠联合超早期小骨窗脑出血清除术治疗HICH效果确切,可改善患者神经损伤标志物、炎症因子水平,安全性较高。Objective To explore the effectiveness and safety of sodium aescinate injection combined with ultra-early small bone window cerebral hemorrhage clearance surgery in the treatment of hypertensive intracerebral hemorrhage(HICH).Methods A total of 86 HICH patients admitted to the First People’s Hospital of Nanyang from August 2021 to July 2022 were selected and randomly divided into a study group and a control group,with 43 patients in each group.The control group received ultra early small bone window cerebral hemorrhage clearance surgery,while the study group received injection of sodium aescinat combined with ultra-early small bone window cerebral hemorrhage clearance surgery.The clinical efficacy,nerve injury markers,inflammatory factors and safety of the two groups were compared.Results The total effective rate of treatment in the study group(90.70%)was higher than that in the control group(72.09%)(P<0.05).After treatment,the levels of neuron specific enolase(NSE),myelin basic protein(MBP)and glial fibrillary acidic protein(GFAP)in the two groups decreased(P<0.05),and the levels in the study group were lower than those in the control group(P<0.05),the levels of interleukin-1β(IL-1β),interleukin 6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)decreased(P<0.05),and the levels in the study group were lower than those in the control group(P<0.05).There was no statistically difference in the incidence of adverse reactions between the study group(11.63%)and the control group(6.98%)(P>0.05).Conclusion The combination of sodium aescinate injection and ultra-early small bone window cerebral hemorrhage clearance surgery is effective in treating HICH,and can improve the levels of nerve injury markers and inflammatory factors in patients,with high safety.

关 键 词：高血压脑出血 注射用七叶皂苷钠 超早期小骨窗脑出血清除术 有效性 安全性 

分 类 号：R743.2[医药卫生—神经病学与精神病学]