血清甲状腺球蛋白水平与分化型甲状腺癌患者临床病理特征的相关性及对术后转移的诊断价值  

Correlation Between Serum Thyroglobulin Levels and the Clinical Pathological Features of Patients with Differentiated Thyroid Cancer and Their Diagnostic Value for Postoperative Metastases

作　　者：林素芳 丁超 孙文聪 汲冬冬 LIN Sufang;DING Chao;SEN Wencong(Henan People's Hospital,Zhengzhou,450000)

机构地区：[1]河南省人民医院,郑州大学人民医院,450000

出　　处：《实用癌症杂志》2023年第7期1078-1081,共4页The Practical Journal of Cancer

摘　　要：目的分析血清甲状腺球蛋白(Tg)在分化型甲状腺癌(DTC)术后转移中的诊断效能。方法选取96例DTC患者,全部患者均停用甲状腺素片4~6周。所有患者在术后行碘治疗,在碘治疗1 d前测定所有患者的Tg水平;并于施行碘治疗1周之后给予SPECT/CT显像,依据显像结果把所有患者划分成复发转移组与非复发转移组,探究2组术后血清Tg水平的不同,明晰术后血清Tg水平与DTC患者临床病理特征之间的联系;另外,描绘受试者工作曲线(ROC),探究血清Tg水平对于DTC患者术后转移的预测功效。结果复发转移组的术后血清Tg水平高于非复发转移组,有统计学差异(P<0.05)。术后血清Tg水平与DTC患者的年龄、肿物内部微钙化、性别无关(P>0.05);术后血清Tg水平与DTC患者的肿瘤位置、肿瘤最大直径、病灶数量以及肿物内部与周边血流有关(P<0.05)。ROC曲线显示:术后血清Tg水平对DTC患者术后转移的预测效能较高,其曲线下面积(AUC)为0.968,标准误为0.019,P为0.000,95%CI为0.931~1.000。结论术后血清Tg水平的检测能够预测DTC术后转移,可有效评估DTC复发转移情况,有利于临床制定针对性的处理方案,以改善预后。Objective To analyze the diagnostic efficacy of serum thyroglobulin(Tg)in postoperative metastasis of differentiated thyroid cancer(DTC).Methods 96 patients with DTC were selected,all of whom stopped taking thyroid hormone tablets for 4-6 weeks.All patients underwent postoperative iodine therapy and their Tg levels were measured 1 day before iodine therapy;After one week of iodine therapy,SPECT/CT imaging was performed,and all patients were divided into recurrent and non recurrent metastatic groups based on the imaging results.Results The differences in postoperative serum Tg levels between the 2 groups were explored,and the relationship between postoperative serum Tg levels and clinical pathological characteristics of DTC patients was clarified;In addition,describe the receiver operating curve(ROC)and explore the predictive power of serum Tg levels for postoperative metastasis in DTC patients.The postoperative serum Tg levels in the recurrence and metastasis group were higher than those in the non recurrence and metastasis group,with a statistical difference(P<0.05).The postoperative serum Tg level was not significantly correlated with the age,microcalcification within the tumor,or gender of DTC patients,and there was no statistical difference(P>0.05);The postoperative serum Tg levels were correlated with the tumor location,maximum tumor diameter,number of lesions,and internal and peripheral blood flow of DTC patients,with statistical differences(P<0.05).The ROC curve shows that postoperative serum Tg levels have a high predictive power for postoperative metastasis in DTC patients,with an area under the curve(AUC)of 0.968,standard error of 0.019,P of 0.000,and a 95%CI of 0.931~1.000.Conclusion The detection of postoperative serum Tg levels can predict postoperative metastasis of DTC,effectively evaluate the recurrence and metastasis of DTC,and facilitate the development of targeted treatment plans in clinical practice to improve prognosis.

关 键 词：分化型甲状腺癌 甲状腺球蛋白 复发转移 诊断效能 

分 类 号：R736.1[医药卫生—肿瘤]