脉管复康胶囊联合尼麦角林治疗脑梗死后认知障碍瘀血内阻证的临床效果  

Clinical effect of Maiguan Fukang Capsules combined with Nimergoline in treating post-stroke cognitive impairment with syndrome of internal blockade of static blood

作　　者：吴小萍 马龙[2] 武玮[3] 桑媛媛 梁海[1] WU Xiaoping;MA Long;WU Wei;SANG Yuanyuan;LIANG Hai(Department of Pharmacy,Bozhou People’s Hospital,Anhui Province,Bozhou 236800,China;Department of Internal Neurology,Bozhou People’s Hospital,Anhui Province,Bozhou 236800,China;Department of Endocrinology,Bozhou People’s Hospital,Anhui Province,Bozhou 236800,China)

机构地区：[1]安徽省亳州市人民医院药学部,安徽亳州236800 [2]安徽省亳州市人民医院神经内科,安徽亳州236800 [3]安徽省亳州市人民医院内分泌科,安徽亳州236800

出　　处：《中国医药导报》2023年第17期86-89,共4页China Medical Herald

基　　金：安徽省重点研究与开发计划项目(2022e07020066)。

摘　　要：目的探讨脉管复康胶囊联合尼麦角林治疗脑梗死后认知障碍(PSCI)瘀血内阻证的临床效果。方法选取2021年1月至2022年7月安徽省亳州市人民医院收治的86例PSCI瘀血内阻证患者,根据随机数字表法将其分为对照组(43例)和观察组(43例)。对照组接受尼麦角林治疗,观察组接受脉管复康胶囊联合尼麦角林治疗,两组均治疗8周。比较两组临床疗效及治疗前后的中医证候积分、简易精神状态检查(MMSE)评分、美国国立卫生研究院卒中量表(NIHSS)评分、脑血流速度、血清神经元特异性烯醇化酶(NSE)、超氧化物歧化酶(SOD)、丙二醛(MDA),评价安全性。结果观察组疗效优于对照组(P<0.05)。治疗后,两组中医证候积分、NIHSS评分及NSE、MDA水平均低于治疗前,MMSE评分、SOD水平及左侧大脑中动脉(LMCA)、左侧大脑后动脉(LPCA)、右大脑后动脉(RPCA)血流速度均高于治疗前,且观察组中医证候积分、NIHSS评分及NSE、MDA水平低于对照组,MMSE评分、SOD水平及LMCA、LPCA、RPCA血流速度高于对照组(P<0.05)。两组治疗过程中均未发生明显不良反应。结论脉管复康胶囊联合尼麦角林治疗PSCI瘀血内阻证效果显著,能有效改善患者认知障碍、神经元损伤和脑血流量,减轻氧化应激反应,且安全性高。Objective To investigate the clinical effect of Maiguan Fukang Capsules combined with Nimergoline in treating post-stroke cognitive impairment(PSCI)with syndrome of internal blockade of static blood.Methods A total of 86 patients with PSCI with syndrome of internal blockade of static blood admitted to Bozhou People’s Hospital of Anhui Province from January 2021 to July 2022 were selected and divided into control group(43 cases)and observation group(43 cases)according to the random number table method.The control group was treated with Nimergoline,and the observation group was treated with Maiguan Fukang Capsules combined with Nimergoline.The two groups were treated for eight weeks.The clinical efficacy was compared between two groups,traditional Chinese medicine syndrome score,mini-mental state examination(MMSE)score,National Institutes of Health stroke scale(NIHSS)score,cerebral blood flow velocity,serum neuron specific enolase(NSE),superoxide dismutase(SOD),and malondialdehyde(MDA)were compared between the two groups before and after treatment,and the safety was evaluated.Results The curative effect of the observation group was better than that of the control group(P<0.05).After treatment,the traditional Chinese medicine syndrome score,NIHSS score,and levels of NSE and MDA of the two groups were lower than those before treatment,and the MMSE score,SOD level,and blood flow velocity of left middle cerebral artery(LMCA),left posterior cerebral artery(LPCA),right posterior cerebral artery(RPCA)were higher than those before treatment,the traditional Chinese medicine syndrome score,NIHSS score,and levels of NSE and MDA of the observation group were lower than those of the control group,and the MMSE score,SOD level,and blood flow velocity of LMCA,LPCA,RPCA were higher than those of the control group(P<0.05).No obvious adverse reactions occurred in the two groups during the treatment.Conclusion Maiguan Fukang Capsules combined with Nimergoline has a significant effect in the treatment of PSCI with syndrome of interna

关 键 词：脑梗死 认知障碍 脉管复康胶囊 尼麦角林 

分 类 号：R743.3[医药卫生—神经病学与精神病学]