铁死亡在阿尔茨海默病中的研究进展  

Research advances of ferroptosis in Alzheimer's disease

作　　者：李涛 于志超 赵静雯 乔欣蕊 高静 许蓬娟 Li Tao;Yu Zhichao;Zhao Jingwen;Qiao Xinrui;Gao Jing;Xu Pengjuan(School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine;Office of Academic Research,Tianjin Sino-German University of Applied Sciences)

机构地区：[1]天津中医药大学中西医结合学院,天津301617 [2]天津中德应用技术大学科技处,天津300350

出　　处：《重庆医科大学学报》2023年第5期508-511,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:82274318);天津市科技特派员资助项目(编号:20YDTPJC00330);天津中医药大学中西医结合学院2021年研究生创新基金资助项目(编号:ZXYCXLX202108)。

摘　　要：最新研究表明,铁死亡在阿尔茨海默病(Alzheimer's disease,AD)的发生发展中扮演重要角色。本文通过对近年相关国内外文献进行总结,对铁代谢紊乱、谷胱甘肽耗竭和脂质过氧化三种铁死亡主要机制与AD的关系进行分类综述,以期为AD的机制研究提供参考并提示铁死亡有望成为治疗AD的新策略。Recent studies have shown that ferroptosis plays an important role in the occurrence and development of Alzheimer's disease.This article summarizes relevant domestic and foreign literature in recent years,and categorizes and reviews the relation⁃ship between the three main mechanisms of ferroptosis,namely iron metabolism disorder,glutathione(GSH)depletion,and lipid peroxidation,and AD.This finding suggests that ferroptosis may become a new therapeutic strategy to treat and prevent AD in the future.

关 键 词：铁死亡 阿尔茨海默病 谷胱甘肽耗竭 铁代谢紊乱 脂质过氧化 

分 类 号：R741[医药卫生—神经病学与精神病学]