QEEG中慢波与颞叶癫痫患者认知功能障碍相关性分析  

Correlation of slow wave on quantitative electroencephalography with cognitive dysfunction in patients with temporal lobe epilepsy

作　　者：张延玲 李国丽 ZHANG Yanling;LI Guoli(Department of Neurology,School of Clinical Medicine,Inner Mongolia University for Nationalities,Chifeng 024000,China;不详)

机构地区：[1]内蒙古民族大学赤峰临床医学院神经内科,内蒙古赤峰024000 [2]赤峰学院附属医院神经内科,内蒙古赤峰024000

出　　处：《中风与神经疾病杂志》2023年第6期522-525,共4页Journal of Apoplexy and Nervous Diseases

基　　金：内蒙古民族大学2021年硕士研究生科研创新(NMDSS2127)。

摘　　要：目的探究定量脑电图中慢波和认知功能障碍的相关性。方法收集2022年1月-2022年10月在赤峰学院附属医院就诊的颞叶癫痫患者80例,对入组患者进行蒙特利尔MoCa量表检查,并完成定量脑电图监测,计算δ波功率值及(δ+θ)/(α+β)比值(DTABR),并进行相关统计分析。结果颞叶癫痫认知障碍组患者40例,男性23例(占57.5%),女性17例(占42.5%),平均年龄(48.15±14.85),平均受教育年限(9.43±2.50),平均用药年限(8.35±4.55);对照组40例患者中男性21例(占52.5%),女性19例(占47.5%),平均年龄(50.83±15.58),平均受教育年限(9.45±2.45),平均用药年限(9.23±5.14)。认知障碍组和正常对照组在年龄、性别、文化程度、用药年限等方面差异无统计学意义(P>0.05),颞叶癫痫患者认知障碍组和正常对照组Moca评分分别为5~25(21.00±7.00)分和26~29(27.00±2.00)分,两组比较差异有统计学意义(Z=-7.738,P<0.05)。认知障碍组δ波功率值及DTABR均显著高于认知正常对照组(均P<0.05);颞叶癫痫患者认知功能测试指标和QEEG电功率DTABR具有相关性,认知功能测试指标与δ波功率值、DTABR均呈负相关(P<0.05),而δ波功率值与DTABR呈正相关(P<0.05)。结论颞叶癫痫患者QEEG中慢波与认知障碍存在相关性,提示DTABR可以作为颞叶癫痫患者认知功能筛查的电功率指标。Objective To investigate the correlation of slow wave on quantitative electroencephalography(QEEG)with cognitive dysfunction.Methods A total of 80 patients with temporal lobe epilepsy who attended The Affiliated Hospital of Chifeng University from January to October 2022 were collected.All patients underwent Montreal Cognitive Assessment(MoCA)and QEEG monitoring to calculateδwave power and(δ+θ)/(α+β)ratio(DTABR),and statistical analyses were performed.Results There were 40 patients in the temporal lobe epilepsy+cognitive dysfunction group,among whom there were 23 male patients(57.5%)and 17 female patients(42.5%),with a mean age of(48.15±14.85)years,a mean duration of education of 9.43±2.5 years,and a mean duration of medication of 8.35±4.55 years;there were 40 patients in the control group,among whom there were 21 male patients(52.5%)and 19 female patients(47.5%),with a mean age of 50.83±15.58 years,a mean duration of education of 9.45±2.45 years,and a mean duration of medication of 9.23±5.14 years.There were no significant differences in age,sex,education level,and medication years between the cognitive dysfunction group and the normal control group(P>0.05),and there was a significant difference in MoCA score between the cognitive dysfunction group and the normal control group[21±7(5-25)points vs 27±2(26-29)points,Z=-7.738,P<0.05].The cognitive dysfunction group had significantly higherδwave power and DTABR than the normal control group(P<0.05).In the patients with temporal lobe epilepsy,cognitive function parameters were correlated with electric power and DTABR on QEEG;cognitive function parameters were negatively correlated withδwave power and DTABR(P<0.05),whileδwave power was positively correlated with DTABR(P<0.05).Conclusion There is a correlation between slow wave and DTABR on QEEG in patients with temporal lobe epilepsy,suggesting that DTABR can be used as an electric power indicator for cognitive function screening in patients with temporal lobe epilepsy.

关 键 词：颞叶癫痫 认知功能障碍 定量脑电图 慢波 DTABR 

分 类 号：R742.1[医药卫生—神经病学与精神病学]