新疆地区食管鳞状细胞癌患者HPV16/18感染与其临床病理特征及预后的关系  

Relationships of HPV16/18 infection in patients with esophageal squamous-cell carcinoma in Xinjiang with their clinicopathologic features and prognosis

作　　者：阿丽米热·库尔班 卡吾力·居买 张海平[3] 丹尼尔·多里坤 张力为[3] 买地尼也提·尼亚孜 Alimire Kuerban;Kawuli Jumai;ZHANG Haiping;Dannier Duolikun;ZHANG Liwei;Madiniyet Niyaz(Basic Medical College,Xinjiang Medical University,Urumqi 830054,China;不详)

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830054 [2]新疆医科大学第一附属医院临床医学研究院 [3]新疆医科大学第一附属医院胸外科 [4]新疆医科大学第一附属医院小儿心胸外科

出　　处：《山东医药》2023年第19期1-4,共4页Shandong Medical Journal

基　　金：国家自然科学基金地区科学基金项目(81760532,81960498)。

摘　　要：目的探讨新疆地区食管鳞状细胞癌(ESCC)患者人乳头瘤病毒(HPV)16/18感染与其临床病理特征及预后的关系。方法选取ESCC患者110例,均行根治性手术治疗,术中取ESCC组织。用原位杂交技术检测ESCC组织中HPV16/18阳性表达,HPV16或HPV18检测阳性可判定为HPV16/18感染。对患者进行随访,统计资料完整91例患者的3年生存情况,用Kaplan-Meier法和Cox比例风险模型进行生存分析。结果在30%(33/110)的ESCC组织中观察到呈棕褐色的HPV16/18阳性颗粒,其主要定位于细胞核内。HPV16/18感染与ESCC浸润深度、淋巴结转移、病理分期、脉管侵犯有关(P均<0.05),与性别、年龄及分化程度无关(P均>0.05)。91例患者中HPV16/18阴性61例、HPV16/18阳性30例。HPV16/18阳性患者生存期短于阴性患者,3年生存率低于阴性患者,比较差异均有统计学意义(P均<0.05)。HPV16/18阳性、有淋巴结转移、分化程度低、有脉管侵犯是ESCC患者预后不良的独立危险因素(P均<0.05)。结论HPV16/18感染可能与ESCC的发生发展有关,且提示患者预后不良。Objective To investigate the relationships of human papillomavirus(HPV)16/18 infection in patients with esophageal squamous-cell carcinoma(ESCC)in Xinjiang with their clinicopathologic features and prognosis.Meth⁃ods A total of 110 cases of ESCC patients were selected,and all of them underwent radical operation.The expression of HPV16/18 in ESCC tissues was detected by in situ hybridization.The positive detection of HPV16 or HPV18 could be considered as HPV16/18 infection.Patients were followed up,and the 3-year survival of 91 patients with complete data was counted.The survival of patients was analyzed by Kaplan-meier method and Cox proportional hazards model.Results Brown HPV16/18-positive particles were observed in 30%(33/110)of ESCC tissues,and were mainly localized in the nucleus.HPV 16/18 infection was associated with the depth of invasion,lymph node metastasis,pathological stage and vascular invasion of ESCC(all P<0.05),but not with sex,age or differentiation(P>0.05).Of the 91 patients,61 were HPV16/18 negative and 30 were HPV16/18 positive.The survival of HPV16/18 positive patients was shorter than that of HPV16/18 negative patients,and the 3-year survival rate of HPV16/18 positive patients was significantly lower than that of HPV16/18 negative patients,with statistically significant differences(both P<0.05).Positive HPV 16/18,lymph node metastasis,low differentiation,and vascular invasion were independent risk factors for poor prognosis of ESCC patients(all P<0.05).Conclusion HPV16/18 infection may be related to the development and progression of ESCC,indicating poor prognosis of ESCC patients.

关 键 词：食管鳞状细胞癌 原位杂交 人乳头瘤病毒16 人乳头瘤病毒18 临床病理特征 预后 

分 类 号：R735.1[医药卫生—肿瘤]