芦荟松衍生物的合成及抗氧化活性研究  

Synthesis and Antioxidant Activity of Aloesone Derivatives

作　　者：曾婷婷 李友宾[1] 王雪松 陈煜 崔雪 ZENG Ting-ting;LI You-bin;WANG Xue-song;CHEN Yu;CUI Xue(Hainan Provincial Key Laboratory of Tropical Medicinal Plant Research and Development,Hainan Medical College,Hainan Haikou 570100,China)

机构地区：[1]海南省热带药用植物研究开发重点实验室海南医学院,海南海口570100

出　　处：《广州化工》2023年第7期43-45,共3页GuangZhou Chemical Industry

基　　金：国家自然科学基金(编号81460591)。

摘　　要：芦荟松为芦荟含有的色酮类化合物,具有较强的抗氧化活性。以3,5-二羟基甲苯为起始原料,通过Friedel-Crafts、酯化、重排、环合反应合成芦荟松2-C位被环烯烃取代、7-OH烷基化的衍生物8个,其中6个为新化合物。抗氧化活性测试结果表明用不同的环烯烃取代2-C位丙酮基后,抗氧化活性显著增加IC_(50)值为0.25~0.32 mM,7-OH甲基化对活性影响不大,乙基化后活性显著下降IC_(50)值0.8~14.88 mM,2-C,7-OH同时修饰活性也会下降IC_(50)值为12.73~43.41 mM。Aloesone is a chromone compound contained in aloe vera,which has antioxidant activity.Eight derivatives with 2-C substituted cycloalkenes and 7-OH alkylation at the aloesone position were synthesized from 3,5-dihydroxytoluene by Friedel-Crafts,esterification,rearrangement and cyclization,of which 6 were new compounds.Antioxidant activity test results showed that after replacing the 2-C acetone group with different cyclic alkenes,the antioxidant activity was significantly increased.IC_(50) value was 0.25~0.32 mM.7-OH methylation had little effect on the activity.Significantly decreased IC_(50) value of 0.8~14.88 mM,2-C,7-OH modification activity also decreased IC_(50) value of 12.73~43.41 mM.

关 键 词：芦荟 芦荟松衍生物 化学合成 DPPH 抗氧化活性 

分 类 号：TQ244[化学工程—有机化工]