MSCT联合CA153、NSE、CEA诊断原发性肺癌的价值分析  

Value of MSCT combined with CA153,NSE,and CEA in the diagnosis of primary lung cancer

作　　者：杨慧[1] 刘继伟[1] 于喜红[1] 杨瑞[1] YANG Hui;LIU Jiwei;YU Xihong;YANG Rui(Department of Medical Imaging,Henan Provincial Chest Hospital.The Affiliated Chest Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052)

机构地区：[1]河南省胸科医院·郑州大学附属胸科医院医学影像科,河南郑州450052

出　　处：《分子诊断与治疗杂志》2023年第6期1047-1050,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技攻关计划项目(20200523101251)。

摘　　要：目的分析MSCT与癌抗原153(CA153)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)联合诊断原发性肺癌的效果。方法选择2021年8月至2022年9月期间于河南省胸科医院诊治的146例原发性肺癌患者纳入肺癌组,同期选择96例良性肺病患者作为良性组,另选68名健康体检志愿者纳入健康组,所有研究对象均进行血清CA153、NSE、CEA及MSCT影像检查,对比三组研究对象、不同病理分期原发性肺癌患者的CA153、NSE、CEA水平,并分析原发性肺癌MSCT影像检查结果及各检查诊断价值。结果三组CA153、NSE、CEA水平呈现:肺癌组>良性组>健康组,差异有统计学意义(P<0.05);不同分期CA153、NSE、CEA水平比较:Ⅲ~Ⅳ期>Ⅱ期>Ⅰ期,差异有统计学意义(P<0.05);经CA153、NSE、CEA检测分别得出83例、79例、81例阳性患者及63例、67例、65例阴性患者;经MSCT检查得74例阳性患者,72例阴性患者;CA153+NSE+CEA+MSCT联合检查的诊断效能显著高于单项检查。结论原发性肺癌CA153、NSE、CEA水平存在异常表现,可能参与肺癌发生、进展过程,上述指标结合MSCT影像学表现可为临床诊断原发性肺癌提高可靠资料。Objective To analyze the efficacy of MSCT combined with cancer antigen 153(CA153),neuron specific enolase(NSE),and carcinoembryonic antigen(CEA)in the diagnosis of primary lung cancer.Methods 146 patients with primary lung cancer diagnosed and treated in Henan Thoracic Hospital from August 2021 to September 2022 were selected for inclusion in the lung cancer group,another 68 healthy volunteers were selected as the healthy group,all research subjects underwent CA153,NSE,CEA,and MSCT imaging examinations,and the CA153,NSE,and CEA levels of primary lung cancer patients with different pathological stages were compared among the three groups,and the primary lung cancer MSCT image examination results and the diagnostic value of each examination were analyzed.Results The levels of CA153,NSE,and CEA in the three groups were lung cancer group>benign group>healthy group,the difference is statistically significant(P<0.05).The levels of CA153,NSE,and CEA in different stages:StageⅢ~Ⅳ>StageⅡ>StageⅠ,the difference is statistically significant(P<0.05).83,89,81positive patients and 63,67,65 negative patients were detected by CA153,NSE,and CEA,respectively.There were 74 positive patients and 72 negative patients by MSCT;the diagnostic efficiency of CA153+NSE+CEA+MSCT combined examination was significantly higher than single examination.Conclusion Abnormal levels of CA153,NSE,and CEA in primary lung cancer may be involved in the occurrence and progression of lung cancer.The above indicators combined with MSCT imaging findings can provide reliable data for clinical diagnosis of primary lung cancer.

关 键 词：原发性肺癌 MSCT影像学表现 CA153 NSE CEA 

分 类 号：R734.2[医药卫生—肿瘤]